Trifluoromethyl substituted analogs of quinine and quinidine
Trifluoromethyl substituted analogs of quinine and quinidine are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl-(or vinyl)-quinuclidine-2 ξ-carboxaldehyde or the corresponding quinuclidine-2 ξ-carboxylic acid alkyl ester. The end products are useful as antimalarial agents.
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(2008/06/13)
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