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57132-53-3

PROGLUMETACIN MALEATE is a carboxylic ester derived from the formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropyl-alpha-glutaminate. It is used as a dimaleate salt to control pain and inflammation associated with musculoskeletal and joint disorders. Upon oral administration, it is metabolized into indometacin and proglumide, which has antisecretor effects that help prevent injury to the stomach lining.

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  • 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethylester

    Cas No: 57132-53-3

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  • 57132-53-3 Structure

  • Basic information

    1. Product Name: PROGLUMETACIN MALEATE
    2. Synonyms: PROGLUMETACIN;PROGLUMETACIN MALEATE;Proglumetacine;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI);1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
    3. CAS NO:57132-53-3
    4. Molecular Formula: C46H58ClN5O8
    5. Molecular Weight: 1076.58
    6. EINECS: 261-656-3
    7. Product Categories: N/A
    8. Mol File: 57132-53-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 900.4 °C at 760 mmHg
    3. Flash Point: 498.3 °C
    4. Appearance: /
    5. Density: 1.22 g/cm3
    6. Vapor Pressure: 3.59E-33mmHg at 25°C
    7. Refractive Index: 1.592
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: PROGLUMETACIN MALEATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: PROGLUMETACIN MALEATE(57132-53-3)
    12. EPA Substance Registry System: PROGLUMETACIN MALEATE(57132-53-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 57132-53-3(Hazardous Substances Data)

57132-53-3 Usage

Uses

Used in Pharmaceutical Industry:
PROGLUMETACIN MALEATE is used as an anti-inflammatory and analgesic agent for controlling pain and inflammation associated with musculoskeletal and joint disorders. Its dual action of reducing inflammation and providing pain relief makes it a valuable treatment option for patients suffering from these conditions.
Used in Gastrointestinal Protection:
PROGLUMETACIN MALEATE is used as a protective agent for the stomach lining due to its metabolite, proglumide, which has antisecretor effects. This helps in preventing injury to the stomach lining, making it a safer option for long-term use and reducing the risk of gastrointestinal side effects commonly associated with nonsteroidal anti-inflammatory drugs (NSAIDs).

Check Digit Verification of cas no

The CAS Registry Mumber 57132-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,1,3 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57132-53:
(7*5)+(6*7)+(5*1)+(4*3)+(3*2)+(2*5)+(1*3)=113
113 % 10 = 3
So 57132-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)

57132-53-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name proglumetacin

1.2 Other means of identification

Product number -
Other names PROGLUMETACIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57132-53-3 SDS

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