- A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group
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Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.
- Obushak, M. D.,Pokhodylo, N. T.,Shyyka, O. Ya.
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p. 802 - 812
(2020/07/03)
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- ANTI-BACTERIAL COMPOUNDS
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A compound of Formula (II): for use in the prevention or treatment of a bacterial infection.
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Page/Page column 90
(2017/06/28)
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- NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME
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Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10);R5 and R6 are independently selected from H, alkyl and halogen;Y is R7(CH2)s or is absent; andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
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Page/Page column 78
(2008/06/13)
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- High affinity phenylglycinol-based NK1 receptor antagonists
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Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK1 (hNK1) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK1 receptor.
- Owens,Harrison,Moseley,Swain,Sadowski,Cascieri
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- The tetrazolylmethyl and related radicals: A convenient access to tetrazoles and other heterocyclic derivatives
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The tetrazole unit can be simply introduced by addition of the 5- tetrazolmethyl radical to a variety of terminal olefins using the xanthate transfer technology; the same principle can be applied to other heterocyclic systems such as imidazoles and benzothiazoles.
- Biadatti, Thibaud,Quiclet-Sire, Beatrice,Saunier, Jean-Baptiste,Zard, Samir Z.
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- Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers
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Tetrazole derivatives of the formula: STR1 wherein R1 is an optional defined substituent; A is sulfur or a lower alkylene-thio; l is 0 or 1; B is a lower alkylene; R2 is hydroxy, a lower alkoxy, or a group: STR2 wherein R3 and R4 are optional defined substituents, or the R3 and R4 may combine together with the nitrogen atom to which they are joined to form a defined heterocyclic group, and a pharmaceutically acceptable salt thereof, which have prophylactic or therapeutic activities against peptic and/or duodenal ulcers and also anti-inflammatory activity and are useful as an anti-ulcer or anti-inflammatory drug; processes for the preparation of the tetrazole derivatives; and pharmaceutical composition containing said tetrazole derivatives.
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- Synthese d'analogues tetrazoles de l'acide phosphonoacetique
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Several routes to 5-(phosphonomethyl)-1(H)-tetrazole, a new antiviral agent, have been investigated.
- Yaouanc,Sturtz,Kraus,Chastel,Colin
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p. 2689 - 2692
(2007/10/02)
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