- Adamantyl quinazoline compound, composition and application of adamantyl quinazoline compound and composition
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The invention discloses an adamantyl quinazoline compound, a composition and application of the adamantyl quinazoline compound and the composition. The compound shown in a formula (I) and all possible isomers or pharmaceutically acceptable salts or hydrates or compositions are used to treat diseases caused by EGFR (Epidermal Growth Factor Receptor) tyrosine kinase, and are particularly used to treat non-small cell lung cancer, small cell lung cancer, squamous-cell carcinoma, breast cancer and gastric carcinoma.
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Paragraph 0060; 0068
(2017/10/07)
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- N-SUBSTTTUTED ANILINES, INHIBITORS OF PHOSPHOLIPASES A2
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Compounds of the formula wherein R1, R2, R3, R4, Rs, Re, R7, R8, n, m, o, p and q are as hereinafter set forth, and, when R2 is hydrogen, pharmaceutically acceptable salts thereof with bases,are described. The compounds of formula 1 are potent inhibitors of phospholipases A2 (PLA2's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury
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