- Sulfamates as antiglaucoma agents
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Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.
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- Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
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Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
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- FACILE SYNTHESIS OF 3-OXO-1,2,5-THIADIAZOLES; 7β-CEPHALOSPHORINS
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A simple procedure is described for the preparation of 3-oxo-1,2,5-thiadiazoles under mild conditions.This procedure has provided hitherto unknown 7β-3-oxo-1,2,5-thiadiazol-2-yl)cephalosporins.
- Lunn, W. H. W.,Shadle, J. K.
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p. 8615 - 8620
(2007/10/02)
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- SULFUR NITRIDE IN ORGANIC CHEMISTRY. 12. THE REACTION OF N4S4 WITH 1-ARYL-1-TRIMETHYLSILYLOXYETHYLENES AFFORDING 3-HYDROXY-4-ARYL-1,2,5-THIADIAZOLES
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Reaction of N4S4 with 1-aryl-1-trimethylsilyloxyethylenes (1a-1e) gave 3-hydroxy-4-aryl-1,2,5-thiadiazoles (2a-2e) though the yields were low. 3-Amino-4-thienyl-1,2,5-thiadiazole (3) was obtained as a minor product.
- Mataka, Shuntaro,Takahashi, Kazufumi,Tashiro, Masashi
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p. 2047 - 2050
(2007/10/02)
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- Studies on Mesoionic Compounds. Part 10. Synthesis and Chemical Properties of Mesoionic 1,2,5-Thiadiazolium-3-olates
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The preparation of a novel mesoionic heterocycle is described; derivatives of 4-aryl-5-alkyl-1,2,5-thiadiazolium-3-olates (6a-f) are obtained by treatment of α-N-substituted aminophenylacetamides with sulphur monochloride followed by base.
- Masuda, Katsutada,Adachi, Jun,Nomura, Keiichi
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p. 1033 - 1036
(2007/10/02)
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- Sulfur Nitride in Organic Chemistry. 9. The Reaction of Tetrasulfur Tetranitride with Benzyl Ketones. Preparation of 3,4-Disubstituted-1,2,5-thiadiazoles
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The reaction of tetrasulfur tetranitride (1) with various aryl and benzyl ketones (2a-o), oxindole (11), benzyl α-pyridyl ketone (12) and α-phenacylpyridine (13) afforded the corresponding 1,2,5-thiadiazoles (3a-n, 11 and 14).The scope and limitations of the above reaction were investigated and the evidences suggesting the radical anion mechanism are presented.
- Mataka, Shuntaro,Hosoki, Akira,Takahashi, Kazufumi,Tashiro, Masashi
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p. 1681 - 1685
(2007/10/02)
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