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573935-28-1

AKOS BBS-00005471 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 573935-28-1 Structure

  • Basic information

    1. Product Name: AKOS BBS-00005471
    2. Synonyms: AKOS BBS-00005471;ASISCHEM C36460;6-(Chloromethyl)-N-(4-ethylphenyl)-1,3,5-triazine-2,4-diamine;[4-amino-6-(chloromethyl)-s-triazin-2-yl]-(4-ethylphenyl)amine;STK138186;ZINC00529976
    3. CAS NO:573935-28-1
    4. Molecular Formula: C12H14ClN5
    5. Molecular Weight: 263.73
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 573935-28-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: AKOS BBS-00005471(CAS DataBase Reference)
    10. NIST Chemistry Reference: AKOS BBS-00005471(573935-28-1)
    11. EPA Substance Registry System: AKOS BBS-00005471(573935-28-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 573935-28-1(Hazardous Substances Data)

573935-28-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 573935-28-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,3,9,3 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 573935-28:
(8*5)+(7*7)+(6*3)+(5*9)+(4*3)+(3*5)+(2*2)+(1*8)=191
191 % 10 = 1
So 573935-28-1 is a valid CAS Registry Number.

573935-28-1Downstream Products

573935-28-1Relevant articles and documents

LPAAT-β INHIBITORS FOR TREATMENT OF CANCER

-

, (2020/07/05)

The present invention relates to a compound of formula (1), wherein R1 and R4 are selected from halogen, small hydrocarbon or alkoxy moieties, R2 is a short alkyl moiety, and X is selected from -S-, -O-, -N(R5)-

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2

Poirier, Marion,Awale, Mahendra,Roelli, Matthias A.,Giuffredi, Guy T.,Ruddigkeit, Lars,Evensen, Lasse,Stooss, Amandine,Calarco, Serafina,Lorens, James B.,Charles, Roch-Philippe,Reymond, Jean-Louis

supporting information, p. 224 - 236 (2018/12/13)

By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2.gdb.tools), which suggested lysophosphatidic acid acyltransferase β (LPAAT-β) as a possible target for this aminotriazine as well as several analogues identified by structure–activity relationship profiling. LPAAT-β inhibition (IC50 ≈15 nm) was confirmed in a biochemical assay and by its effects on cell proliferation in comparison with a known LPAAT-β inhibitor. These experiments illustrate the value of target-prediction tools to guide target identification for phenotypic screening hits and significantly expand the rather limited pharmacology of LPAAT-β inhibitors.

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