Low-temperature method for enhancement of enantioselectivity in the lipase-catalyzed kinetic resolutions of solketal and some chiral alcohols
Low-temperature method (-40 °C at best) for enhancement of the enantioselectivity in a lipase-catalyzed transesterification was proved to be widely applicable to primary and secondary alcohols and enabled theoretical prediction of the course of enhancement of the enantioselectivity physicochemically.
Lipase-catalysed Transesterification in the preparation of Optically Active Solketal
A lipase-catalysed method for a large-scale preparation of both (R)- ee 99percent) and (S)-solketal (ee 94percent after double resolution) has been described.Separation of the reaction products in the resolution mixture was achieved by extraction/distillation and the unwanted enantiomer was racemized and recycled.
Vaenttinen, Eero,Kanerva, Liisa T.
p. 3459 - 3464
(2007/10/02)
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