Strategy to Prepare 3-Bromo- and 3-Chloropyrazoles
A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable preparation of a wide variety of 3-halopyrazoles with good to excellent yields and regiocontrol.
Fox, Richard J.,Schmidt, Michael A.,Eastgate, Martin D.
p. 2830 - 2839
(2018/03/09)
Chemical Properties
Boiling Point: 212 ºC
Flash Point:82 ºC
Density: 1.58
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
