- Intermolecular Benzyne Cycloaddition Approach to Aporphinoids. Total Syntheses of Norcepharadione B, Cepharadione B, Dehydroanonaine, Duguenaine, Dehydronornuciferine, Pontevedrine, O-Methylatheroline, Lysicamine, and Alkaloid PO-3
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We describe a useful novel approach to the synthesis of aporphinoids, including dehydroaporphines, aristolactams, 4,5-dioxoaporphines, and 7-oxoaporphines, by means of intermolecular benzyne cycloaddition (IBC).Specifically, we report the total synthesis of the isoquinoline alkaloids norcepharadione B, cepharadione B, dehydroanonaine, deguenaine, dehydronornuciferine, pontevedrine, O-methylatheroline, lysicamine, and alkaloid PO-3.
- Atanes, N.,Castedo, L.,Guitian, E.,Saa, C.,Saa, J. M.,Suau, R.
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p. 2984 - 2988
(2007/10/02)
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- NEW BENZYNE APPROACH TO THE SYNTHESIS OF DEHYDROAPORPHINES, 4,5-DIOXOAPORPHINES AND ARISTOLACTAMS
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A new strategy for the synthesis of some aporphinoid alkaloids is described.It is based on the intermolecular Diels-Alder cyclization between benzyne and an appropriate methylene isoquinoline derivative.
- Castedo, Luis,Guitian, Enrique,Saa, Jose M.,Suau, Rafael
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p. 457 - 458
(2007/10/02)
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