- Method for synthesizing glyphosate
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The invention provides a method for synthesizing glyphosate. The method comprises the following steps: firstly, reacting a compound with a structure shown in a formula (I), paraformaldehyde, an organic solvent, water and a catalyst in a mixed gas atmosphere of carbon monoxide and hydrogen to obtain a compound with a structure shown in a formula (II); then, mixing and hydrolyzing the compound withthe structure shown in the formula (II) and concentrated hydrochloric acid to obtain the glyphosate, specifically, the compound with the structure shown in the formula (I) is used as a reaction raw material to prepare the glyphosate, the source of the reaction raw material is wide, and dimethyl phosphite is not needed to be synthesized as a reaction raw material to prepare the compound with the structure shown in the formula (I), but only phosphorous acid or even phosphorus trichloride can be directly used instead; a byproduct acetic acid prepared in the preparation process of the glyphosate can be used for preparing acetamide for recycling; and compared with an existing method for preparing glyphosate, the method has the advantages that the raw material utilization rate is higher, the process route is simplified, the generated waste liquid is less, and the method has good industrial application prospect.
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Paragraph 0038-0039; 0045-0046; 0052-0053; 0059-0060
(2019/07/10)
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- Amide phosphonic acid metal complex, a corresponding composite material and its preparation method
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The invention discloses amide phosphonic acid metal complex, a corresponding composite material and preparation methods thereof. The structure of the complex is as shown in the formula (A), wherein R is H, CH3, C6H5 or CH2=CH-; M is Cu, Co, Ni, Ba or Sr. The amide phosphonic acid metal complex (A) is prepared by using a corresponding amide compound and formaldehyde (or metaformaldehyde) as raw materials, carrying out reaction between the raw materials and H3PO3, and conducting complexing on the reaction product and corresponding metal ions M. The amide phosphonic acid metal complex (A), a high-frequency medium ceramic additive, thermoplastic resin and the like are mixed; pelletization, injection moulding and forming are conducted on the mixture; after high-energy particle irradiation, a metalized rough surface is formed, so as to conveniently realize circuit wiring, and precipitate metal through chemical plating to further obtain a firmly combined fine three-dimensional molding interconnection device or a three-dimensional circuit (3D-MID). Therefore, various antennae of different uses can be integrated to greatly reduce the geometric dimensioning the antennae or an electronic device, ensure the electronic product to be smaller, lighter, thinner and more flexible, greatly simplify the production process, and obviously reduce the cost.
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Paragraph 0036-0037
(2017/06/08)
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- METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID
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The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P-O-P anhydride moiety comprising compound, having one P-atom at the oxidation state (+111) and the other P-atom at the oxidation state (+111) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P-O-P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.
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Page/Page column 23
(2014/02/15)
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- Tritylamine (triphenylmethylamine) in organic synthesis; III. The synthesis of 1-aminoalkylphosphonic acids in the reaction of N-(triphenylmethyl) alkanimines with phosphorus trichloride in acetic acid or with phosphonic (phosphorous) acid in acetic anhydride
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The reaction of phosphorus trichloride in acetic acid or phosphonic (phosphorous) acid in acetic anhydride, with N-(triphenylmethyl)alkanimines gives 1-acetylaminoalkylphosphonic acids 1a-j, which after hydrolysis give 1-aminoalkylphosphonic acids 2a-j in good yields. ARKAT USA, Inc.
- Goldeman, Waldemar,Soroka, Miroslaw
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experimental part
p. 360 - 369
(2011/02/27)
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- 1-(N-acylamino)alkanephosphonates. Part IV. N-acylation of 1-aminoalkanephosphonic acids
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Practical general procedures of N-acylation of 1-aminoalkanephosphonic acids, including N-acetylation, N-benzoylation and N-pivaloylation of the representative aminophosphonic acids are described. Physico-chemical properties of synthesized derivatives are
- Kudzin,Depczynski,Andrijewski,Drabowicz,Luczak
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p. 499 - 513
(2007/10/03)
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- Preparation of acylaminomethanephosphonic acids and acylaminomethanephosphinic acids
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Acylaminomethanephosphinic acids, and a process for the preparation of acylaminomethanephosphonic acids and acylaminomethylphosphinic acids Acylaminomethanephosphonic acid and acylaminomethylphosphinic acids of the formula I, in which R1/sup
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- CHARACTERIZATION OF 1-AMINOALKANEPHOSPHONIC ACIDS BY CHEMICAL IONIZATION MASS SPECTROMETRY
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Chemical ionization mass spectra (CIMS and DCIMS) of 1-aminoalkanephosphonic acids 1 and their diester derivatives 3 are reported and they are discussed in the context of structural determination. Key words: 1-aminoalkanephosphonic acods, chemical ionizat
- Kudzin, Zbigniew H.,Drabowicz, Jozef,Sochacki, Marek,Wisniewski, Witold
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- Process for the preparation of acylaminomethanephosphonic acids
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Acylaminomethanephosphonic acids are useful intermediates for the preparation of the herbicide N-phosphonemethylglycine and its salts. According to the invention, acylaminomethanephosphonic acids of the formula (I) in which R1 is H, Cs
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- Preparation of N-acyl-aminomethylphosphonates
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N-Acyl-aminomethylphosphonic acids represented by the formula STR1 wherein R is selected from the group consisting of methyl and aryl are prepared by: (a) bringing together under substantially anhydrous reaction conditions an amide represented by the formula STR2 wherein R is as defined above and paraformaldehyde; and thereafter, (b) adding phosphorous trihalide to the reaction mixture.
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- Synthesis, Enzyme-Substrate Interaction, and Herbicidal Activity of Phosphoryl Analogues of Glycine
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The interactions of hydrophosphoryl compounds 1-10 and 1,3,5-triacetylhexahydro-1,3,5-triazine furnish the N-acetylated (aminomethyl)phosphoryl compounds 11-20, which, upon acidic hydrolysis, lead to 3, 6, 9, and 21-24.Strict selectivity is observed in the enzyme-catalyzed hydrolysis with the enzymes α-chymotrypsin, phosphodiesterase I, and alkaline phosphatase.Some of the synthesized materials exhibit herbicidal and antitumor activity.
- Natchev, Ivan A.
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p. 861 - 868
(2007/10/02)
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- Chemical and Mutagenic Analysis of Aminomethylphosphonate Biodegradation
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Utilization of aminomethyl-, N-methylaminomethyl-, N,N-dimethylaminomethyl-, and N-acetylaminomethylphosphonate by Escherichia coli as a sole source of phosphorus during growth resulted in the extracellular generation of N-methylacetamide, N,N-dimethylacetamide, trimethylamine, and N-methylacetamide, respectively.Product identification relied on synthesis of (13)C-enriched aminomethylphosphonates followed by (1)H NMR analysis of products isolated from the biodegradation of the labeled and unlabeled phosphorus sources.To circumvent the requirement of an intact cell for carbon to phosphorus bond degradation, transposon mutagenesis was exploited as a complement to the chemical analysis.E. coli K-12 were infected with λTn5.Colonies resistant to kanamycin were selected and then screened for loss of the ability to use ethylphosphonate as a sole source of phosphorus.The mutant identified, E. coli SL724, was also unable to degrade aminomethylphosphonates.This combination of chemical and mutagenic analysis points toward a shared mechanism between alkyl- and aminomethylphosphonate biodegradation.
- Avila, L. Z.,Loo, S. H.,Frost, J. W.
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p. 6758 - 6764
(2007/10/02)
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