SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS
The present invention relates to substituted tricyclic compounds, which can be used as vanilloid receptor ligands. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by vanilloid receptor-1 (VRl). Also provided herein are pharmaceutical compositions and methods for treating or preventing diseases, conditions and/or disorders modulated by VRl.
-
Page/Page column 30
(2009/07/25)
An Expedient Synthesis of Benzo[h]quinazolin-4(3H)-one: Structure of Samoquasine A Revisited
An expedient four-step synthesis of benzo[h]quinazolin-4(3H)-one (1) starting from 1-tetralone is reported. The claimed identity of samoquasine A with perlolidine (4) has been discussed in the light of the present synthesis.