PREPARATION AND FACILE CYCLIZATION OF 5-ALKYN-1-YLLITHIUMS
Primary 5-hexyn-1-yllithiums, which may be generated in virtually quantitative yield by low-temperature lithium-iodine interchange, undergo regiospecific 5-exo-dig cyclization via stereoselectively syn-addition of CH2Li to the alkyne moiety to give vinyllithiums that may be trapped with any of a variety of electrophiles to deliver functionalized cyclopentylidene-containing products.
Bailey, William F.,Ovaska, Timo V.,Leipert, Thomas K.
p. 3901 - 3904
(2007/10/02)
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