Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Incorporating the 1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) Alkylation Subunit
An efficient eight-step synthesis (53% overall) and the evaluation of 1,2,9,9a-tetrahydrocyclopropa-[c]benz[e]-3-azaindol-4-one (CBA) and its derivatives containing an aza variant of the CC-1065/ duocarmycin alkylation subunit are detailed. This unique de
Parrish, Jay P.,Kastrinsky, David B.,Hwang, Inkyu,Boger, Dale L.
p. 8984 - 8990
(2007/10/03)
Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone
(Matrix presented) An efficient eight-step synthesis (54% overall) and the subsequent X-ray characterization of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) containing an aza variant of the CC-1065/duocarmycin alkylation subunit are deta
Parrish, Jay P.,Kastrinsky, David B.,Boger, Dale L.
p. 2577 - 2579
(2007/10/03)
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