57784-96-0Relevant articles and documents
Nonproteinogenic Amino Acids, IV. - EPC Synthesis of L-(+)-Forphenicine
Weinges, Klaus,Reinel, Ute,Maurer, Wolfgang,Gaessler, Norbert
, p. 833 - 838 (2007/10/02)
Enantiomerically pure L-(+)-forphenicine (12) is synthesized starting from purchasable 3-methoxybenzaldehyde (1) by the use of (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (2) as a chiral auxiliary and prussic acid. 12 is identical with the natural product which has been isolated from the culture broth of an Actinomyces species and which is known to be a potent inhibitor of alkaline phosphatase.