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AC-GLY-ALA-LYS(AC)-AMC is a fluorogenic substrate specifically designed for the detection and quantification of protease activity. It is composed of a peptide sequence that includes an N-terminal acetyl group, followed by the amino acids glycine, alanine, and lysine with an acetyl group, and a C-terminal 7-amino-4-methylcoumarin (AMC) moiety. The unique structure allows for the release of the AMC group upon cleavage by proteases, such as trypsin or chymotrypsin, which results in the emission of a fluorescent signal. This signal can be detected and measured, offering a reliable quantitative assay for assessing protease activity. AC-GLY-ALA-LYS(AC)-AMC is widely utilized in research and diagnostic settings for the study of protease functions and the screening of protease inhibitors.

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  • 577969-56-3 Structure
  • Basic information

    1. Product Name: AC-GLY-ALA-LYS(AC)-AMC
    2. Synonyms: AC-GLY-ALA-LYS(AC)-AMC;Ac-GAK(Ac)-AMC
    3. CAS NO:577969-56-3
    4. Molecular Formula: C25H33N5O7
    5. Molecular Weight: 515.55882
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 577969-56-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: AC-GLY-ALA-LYS(AC)-AMC(CAS DataBase Reference)
    10. NIST Chemistry Reference: AC-GLY-ALA-LYS(AC)-AMC(577969-56-3)
    11. EPA Substance Registry System: AC-GLY-ALA-LYS(AC)-AMC(577969-56-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 577969-56-3(Hazardous Substances Data)

577969-56-3 Usage

Uses

Used in Research Applications:
AC-GLY-ALA-LYS(AC)-AMC is used as a research tool for the detection and quantification of protease activity, enabling scientists to study the function and regulation of proteases in various biological processes.
Used in Diagnostic Applications:
In the diagnostic industry, AC-GLY-ALA-LYS(AC)-AMC serves as a diagnostic agent to assess protease activity levels, which can be indicative of certain diseases or conditions, thus aiding in disease diagnosis and monitoring.
Used in Drug Discovery and Development:
AC-GLY-ALA-LYS(AC)-AMC is utilized as a screening substrate in drug discovery and development for identifying and characterizing potential protease inhibitors. This application is crucial for the development of therapeutic agents targeting protease-related diseases.
Used in Enzyme Kinetics Studies:
In the field of enzymology, AC-GLY-ALA-LYS(AC)-AMC is employed as a substrate to investigate enzyme kinetics, providing insights into the catalytic mechanisms and substrate specificity of proteases.
Used in Quality Control of Protease Inhibitors:
AC-GLY-ALA-LYS(AC)-AMC is used as a quality control substrate to assess the efficacy and potency of protease inhibitors, ensuring the reliability and consistency of these therapeutic agents in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 577969-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,7,9,6 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 577969-56:
(8*5)+(7*7)+(6*7)+(5*9)+(4*6)+(3*9)+(2*5)+(1*6)=243
243 % 10 = 3
So 577969-56-3 is a valid CAS Registry Number.

577969-56-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name acetyl-Gly-Ala-(N-acetyl-Lys)-AMC

1.2 Other means of identification

Product number -
Other names AC-GLY-ALA-LYS(AC)-AMC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:577969-56-3 SDS

577969-56-3Downstream Products

577969-56-3Relevant articles and documents

INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

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, (2008/06/13)

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the acitivy of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.

SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

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Page/Page column 97, (2008/06/13)

The present invention is directed to certain silanol derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for p

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