578028-25-8Relevant articles and documents
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability
Saitoh, Morihisa,Kunitomo, Jun,Kimura, Eiji,Iwashita, Hiroki,Uno, Yumiko,Onishi, Tomohiro,Uchiyama, Noriko,Kawamoto, Tomohiro,Tanaka, Toshimasa,Mol, Clifford D.,Dougan, Douglas R.,Textor, Garret P.,Snell, Gyorgy P.,Takizawa, Masayuki,Itoh, Fumio,Kori, Masakuni
experimental part, p. 6270 - 6286 (2010/03/24)
Glycogen synthase kinase 3β (GSK-3β) inhibition is expected to be a promising therapeutic approach for treating Alzheimer's disease. Previously we reported a series of 1,3,4-oxadiazole derivatives as potent and highly selective GSK-3β inhibitors, however,
AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES
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Page 70-71, (2008/06/13)
The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.