One-pot access to a library of structurally diverse nicotinamide derivatives via a three-component formal Aza [3 + 3] cycloaddition
The three-component formal [3 + 3] aza-annulation between chalcones, β-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C-C and two C-N bonds in a single synthetic operation and involves up to five individual steps.
Tenti, Giammarco,Teresa Ramos,Carlos Menendez
p. 551 - 557
(2013/02/22)
Synthesis of methylpyridine derivative. XXXI. Reaction of acetoacetamide with α,β unsaturated ketones and aldehydes
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Kato,Noda
p. 2193 - 2200
(2007/10/05)
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