Reactive Langmuir-Blodgett membrane for biosensor applications. Use of succinimidyl behenoate-based membranes as support for covalently immobilizing α-chymotrypsin
Succinimidyl behenoate was synthesized to prepare Langmuir-Blodgett (LB) membranes which possess reactive groups on the surface. The surface of the succinimidyl behenoate-based LB membrane could be covalently modified with α-chymotrypsin, for the purpose of biosensor applications.
DNA micelles as nanoreactors: Efficient DNA functionalization with hydrophobic organic molecules
We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.
Trinh, Tuan,Chidchob, Pongphak,Bazzi, Hassan S.,Sleiman, Hanadi F.
supporting information
p. 10914 - 10917
(2016/09/09)
Synthesis and Biological Activities of N-Acetylglucosaminyl-&β(1->4)-N-Acetylmuramyl Tri- and Tetrapeptide Derivatives
The acylated, amidated and esterified derivatives of N-acetylglucosaminyl-β(1->4)-N-acetylmuramyl tri- and tetrapeptide were synthesized and examined as to their protective effect on pseudomonal infection in the mouse and pyrogenicity in the rabbit.Modifications of the terminal end function of the peptide moieties in their molecules caused enhancement of resistance to pseudomonal infection and reduction of pyrogenicity.Among the compounds tested, sodium N-acetylglucosaminyl-β(1->4)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl-(L)-stearoyl-(D)-meso-2,6-diaminopimelic acid-(D)-amide and sodium N-acetylglucosaminyl-β(1->4)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl-(L)-stearoyl-(D)-meso-2,6-diaminopimelic acid-(D)-amide-(L)-D-alanine were found to be advantageous and conceivably worthwhile for further investigation as immunobiologically active compounds.
N-mono-substituted derivatives of diamino acids are prepared by the reaction of succinimidyl esters of carboxylic acids or substituted carbonic acids with the unprotected diamino acid. The acylation preferentially occurs at the side chain or terminal amino group of the diamino acid. For example, selective acylation of the terminal amino group of lysine occurs without first having protected the 2-amino group. Such acylation has application in the preparation of inter alia N6 -palmitoyl-lysine.
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(2008/06/13)
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