582325-32-4

Basic information

• Product Name: 4-(3-Chloropyridin-2-yl)benzoic acid
• Synonyms: 4-(3-Chloropyridin-2-yl)benzoic acid
• CAS NO: 582325-32-4
• Molecular Formula: C₁₂H₈ClNO₂
• Molecular Weight: 233.65
• Mol File: 582325-32-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-Chloropyridin-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Chloropyridin-2-yl)benzoic acid(582325-32-4)
• EPA Substance Registry System: 4-(3-Chloropyridin-2-yl)benzoic acid(582325-32-4)

Safety Data

• Hazardous Substances Data: 582325-32-4(Hazardous Substances Data)

Upstream product

• 847446-86-0 4-(3-chloropyridin-2-yl)benzaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 
• 2402-77-9 2,3-dichloro-pyridine 
• 14047-29-1 4-carboxyphenylboronic acid 
• 892482-36-9 3-chloro-2-(4-methylphenyl)pyridine 

Downstream Products

• 850379-95-2 4-(3-chloro-2-pyridinyl)aniline 
• 849753-78-2 4-(3-Chloro-pyridin-2-yl)-N-(4-trifluoromethyl-phenyl)-benzamide 
• 1282032-82-9 4-(3-chloropyridin-2-yl)benzoyl chloride 

Relevant articles and documents

Benzoimidazole derivatives and pharmaceutical composition comprising the same

Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, pos

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache,

AMIDE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor

The present invention relates to compounds of formula (I) that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.

Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands

Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.

SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES

Substituted bipheny1-4-carboxylic acid arylamide analogues capable of modulating receptor activity, are provided. Such ligands may be used to modulate receptor activity in viva or in vitro, and are particularly useful in the treatment of pain and other co