- Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
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The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1α-hydroxy vitamin D4 and novel analogues, thereof, including 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4. Novel 1α-hydroxy vitamin D4 compounds and compounds of novel analogues suitable for use in the treatment of such disorders are also disclosed herein.
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- Method of inhibiting the hyperproliferation of malignant cells
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1α-hydroxy vitamin D4 and analogues, preferably 1,24 dihydroxy vitamin D4, which are useful as active compounds of pharmaceutical compositions for the inhibition of hyperproliferative activity of malignant cells.
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- Chromyl Halide Oxidation of Steroid Alkenes
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Ergosteryl acetate and CrO2F2 gave 3β-acetoxy-6α-fluoroergosta-7,22-dien-5α-ol.Cholesteryl acetate and CrO2Cl2 gave the α- and β-epoxides, the 5α-chloro-6-ketone, and both 5α,6β-chlorohydrins; cis-chlorohydrins were not detected.Cholesteryl acetate and CrO2F2 gave both epoxides and the 5α-fluoro-6β-alcohol.Unexpectedly, 9,11-dehydrotigogenin acetate and CrO2F2 gave only the 9,11-epoxides with the β-form predominating (5:1).The absence of cis-halogenohydrin formation from simple olefins and CrO2X2 (X = F, Cl) is in conflict with recent studies on acyclic and monocyclic alkenes.
- Barrett, Anthony G. M.,Barton, Derek H. R.,Tsushima, Tadahiko
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p. 639 - 642
(2007/10/02)
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