Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors
Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.
Finn, John,Mattia, Karen,Morytko, Mike,Ram, Siya,Yang, Yingfei,Wu, Ximao,Mak, Elsa,Gallant, Paul,Keith, Dennis
p. 2231 - 2234
(2007/10/03)
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