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CAS

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58479-77-9

5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is a complex organic compound with the molecular formula C10H12N2O6S. It is a nucleoside analog, which means it is structurally similar to a nucleoside, a building block of nucleic acids. This specific compound features a pyrimidine base with a 2-thioxo group, indicating the presence of a sulfur atom in place of an oxygen atom in the ring structure. The molecule also includes a carboxymethyl group attached to the 5-position of the pyrimidine ring and a beta-D-ribofuranosyl sugar moiety, which is a component of RNA. 5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is of interest in medicinal chemistry, particularly in the development of antiviral and anticancer drugs, due to its potential to interfere with nucleic acid synthesis and function.

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  • 58479-77-9 Structure

  • Basic information

    1. Product Name: 5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
    2. Synonyms: 5-Carboxymethyl-2-thiouridine;5-Carboxymethyl-2-thiouridine, 2-thiouridine 5-acetic acid
    3. CAS NO:58479-77-9
    4. Molecular Formula: C11H14N2O7S
    5. Molecular Weight: 318.3031
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 58479-77-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.78g/cm3
    6. Refractive Index: 1.732
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(58479-77-9)
    11. EPA Substance Registry System: 5-(carboxymethyl)-1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(58479-77-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 58479-77-9(Hazardous Substances Data)

58479-77-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 58479-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,4,7 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58479-77:
(7*5)+(6*8)+(5*4)+(4*7)+(3*9)+(2*7)+(1*7)=179
179 % 10 = 9
So 58479-77-9 is a valid CAS Registry Number.

58479-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-2-sulfanylidenepyrimidin-5-yl]acetic acid

1.2 Other means of identification

Product number -
Other names 2-Thio-5-carboxymethyluridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58479-77-9 SDS

58479-77-9Downstream Products

58479-77-9Relevant articles and documents

Isolation and characterization of 5-carbamoylmethyluridine and 5- carbamoylmethyl-2-thiouridine from human urine

Chheda,Patrzyc,Tworek,Dutta

, p. 2155 - 2173 (2007/10/03)

Two new modified uracil nucleosides, 5-carbamoylmethyuridine (ncm5U, I) and 5-carbamoylmethyl-2-thiouridine (ncm5s2U, II) were isolated from a 24 hr collection of a normal human urine. The structures were assigned on the basis of UV, NMR and mass spectral data and confirmed by comparison of the spectral data and HPLC mobilities with those of authentic samples. On the basis of experimental data it appears possible that 5-carbamoylmethyl- 2-thio-uridine (ncm5s2U, II) may be a degradation product produced from a labile precursor by the chemical treatments during the isolation procedure. However, the other nucleoside (ncm5U,I) certainly appears to be of metabolic origin and was also found in the urines of one chronic myelogenous leukemia and one lung carcinoma patient.

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