585566-00-3

Basic information

• Product Name: 5-(2-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE
• Synonyms: 2-furancarbonyl chloride, 5-(2-fluorophenyl)-; 5-(2-Fluorophenyl)-2-furoyl chloride; 5-(2-fluorophenyl)furan-2-carbonyl chloride
• CAS NO: 585566-00-3
• Molecular Formula: C₁₁H₆ClFO₂
• Molecular Weight: 224.62
• Mol File: 585566-00-3.mol

Chemical Properties

• Boiling Point: 320.6°C at 760 mmHg
• Flash Point: 147.7°C
• Appearance: /
• Density: 1.335g/cm³
• Vapor Pressure: 0.000314mmHg at 25°C
• Refractive Index: 1.547
• Sensitive: Hygroscopic
• CAS DataBase Reference: 5-(2-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE(585566-00-3)
• EPA Substance Registry System: 5-(2-FLUOROPHENYL)FURAN-2-CARBONYL CHLORIDE(585566-00-3)

Safety Data

• RIDADR: UN3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 585566-00-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H6ClFO2/c12-11(14)10-6-5-9(15-10)7-3-1-2-4-8(7)13/h1-6H

Upstream product

• 852145-96-1 5-(2-fluorophenyl)furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 1993-03-9 o-fluorophenylboronic acid 
• 348-54-9 2-Fluoroaniline 
• 88-14-2 2-furanoic acid 
• 353761-02-1 5-(2-fluorophenyl)furan-2-carboxylic acid 

Downstream Products

• 1354698-16-0 N-5-(2'-fluorophenyl)-2-furoyl-1H-pyrazole 
• 637728-08-6 (5-(2-fluorophenyl)furan-2-yl)methanol 
• 1216141-38-6 5-(2-fluorophenyl)-2-furoylhydrazone 
• 1410785-83-9 C₂₀H₁₄ClFN₂O₃ 
• 1145781-21-0 4-chlorobenzaldehyde (5-(2-fluorophenyl)-2-furoyl)hydrazone 
• 1313756-19-2 5-(2-fluorophenyl)-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-2-furancarboxamide 

Relevant articles and documents

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Tetrahydroquinoline and tetrahydroisoquinoline derivatives containing 2-phenyl-5-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds showed good inhibitory activity aga

Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors

A series of pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds exhibited considerable inhibitory activit

Synthesis and bioactivity of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan

A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title c