Synthesis, antiviral evaluation and molecular docking studies of N4-aryl substituted/unsubstituted thiosemicarbazones derived from 1-indanones as potent anti-bovine viral diarrhea virus agents
A series of N4-arylsubstituted thiosemicarbazones derived from 1-indanones and a set of compounds lacking such substitution in the N4 position of the thiosemicarbazone moiety were synthesized and evaluated for their anti-bovine viral
Soraires Santacruz, María C.,Fabiani, Matías,Castro, Eliana F.,Cavallaro, Lucía V.,Finkielsztein, Liliana M.
Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-resistant cells. Exemplary compounds disclosed herein have the structure;Formula (I). Examples of the disclosed compounds have been found to have,
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Page/Page column 40
(2012/03/27)
Synthesis, activity, and pharmacophore development for isatin-β- thiosemicarbazones with selective activity toward multidrug-resistant cells
We have recently identified a new class of compounds that selectively kill cells that express P-glycoprotein (P-gp, MDR1), the ATPase efflux pump that confers multidrug resistance on cancer cells. Several isatin-β- thiosemicarbazones from our initial stud
Hall, Matthew D.,Salam, Noeris K.,Hellawell, Jennifer L.,Fales, Henry M.,Kensler, Caroline B.,Ludwig, Joseph A.,Szakács, Gergely,Hibbs, David E.,Gottesman, Michael M.
experimental part
p. 3191 - 3204
(2010/03/31)
Synthesis and antibacterial activity of thiosemicarbazones and hydrazones derived from indanone 1
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Misra,Varma,Agarwal
p. 981 - 982
(2007/10/15)
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