- An environmentally friendly and cost effective synthesis of estradiol featuring two novel reagents: Si(0)/KF and PMHS/hexamethyldisiloxane/pTSA
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Si(0)/KF is introduced as a strong, inexpensive, environmentally friendly, and safe reagent for 'dissolving metal'-type reduction. PMHS/hexamethyldisiloxane/pTSA is introduced as an inexpensive substitute for Et3SiH/TFA for 'ionic hydrogenation', where the hexamethyldisiloxane functions as a capping agent to block the oligomeric silicone by-product from cross-linking to a gel, rubber, or plastic. An environmentally friendly and cost effective synthesis of estradiol is described which showcases these new reagents.
- Lim, Chongsoo,Evenson, Gerald N.,Perrault, William R.,Pearlman, Bruce A.
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p. 6417 - 6420
(2007/10/03)
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- A Total Synthesis of Estradiol and its 6,6-Dimethyl Analogue
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A short, stereoselective synthesis of estradiol, and its 6,6-dimethyl analogue, was accomplished from non-steroidal starting materials.A key feature was the use of a benzothiophene unit to effect (i) the stereoselective formation of the required 8β-H c
- Collins, Mark A.,Jones, D. Neville
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p. 4467 - 4470
(2007/10/02)
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