Studies of phosphorylation reaction of tertiary amines by NMR spectroscopy
Phosphorylation of tertiary amines containing at least two ethyl groups at the nitrogen atom with phosphorus pentachloride was studied. New C-chlorophosphorylated enamines were characterized by NMR spectroscopy. A scheme was suggested for the phosphorylation reaction. It was found that the presence of two aryl substituents in the molecule of tertiary ethylamine deactivated the ethyl group to block phosphorylation. Phosphorylation of N,N-diethylaniline, besides phenyl-substituted phosphorus-containing enamines, also gave phosphorylated enamines chloro-substituted in the ring. Using N-ethyl-N-methylaniline as an example, a possibility of substitution for two chlorine atoms in the PCl5 molecule with alkenyl groups was demonstrated.
Larina,Rozinov,Komarova
p. 39 - 46
(2013/11/19)
Corey-itsuno reduction of ketones: A development of safe and inexpensive process for synthesis of some API intermediates
A safe and inexpensive procedure for asymmetric reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully to manufacture enantiopure dapoxetine at the plant scale.
Mahale, Rajendra D.,Chaskar, Sudhir P.,Patil, Kiran E.,Maikap, Golak C.,Gurjar, Mukund K.
experimental part
p. 710 - 713
(2012/07/27)
More Articles about upstream products of 5882-45-1