Cyclopentadiene-phosphine/palladium-catalyzed cleavage of C-N bonds in secondary amines: Synthesis of pyrrole and indole derivatives from secondary amines and alkenyl or aryl dibromides
An efficient Pd-catalyzed cleavage of C(sp3)-N bonds in secondary amines and a consequent C(sp2)-N and C(sp3)-N coupling process was developed. Various secondary amines could be used to react with alkenyl or aryl dibromide
Conjugate addition of nitroalkanes to N-substituted maleimides. Synthesis of 3-alkylsuccinimides and pyrrolidines
3-Alkylidenesuccinimides obtained by conjugate addition of nitroalkanes to N-substituted maleimides can be reduced to the corresponding 3-alkyl derivatives by catalytic hydrogenation. 3-Alkylsuccinimides can be further reduced using BH3·Me