588698-71-9

Basic information

• Product Name: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-methyl-
• CAS NO: 588698-71-9
• Molecular Formula: C32H33N5O6
• Molecular Weight: 583.644
• Mol File: 588698-71-9.mol

Chemical Properties

• CAS DataBase Reference: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-methyl-(588698-71-9)
• EPA Substance Registry System: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-methyl-(588698-71-9)

Safety Data

• Hazardous Substances Data: 588698-71-9(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1867-73-8 N⁶-methyladenosine 
• 74465-47-7 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-bromo-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 
• 3181-38-2 2',3',5'-tri-O-acetylinosine 
• 58-63-9 Inosine 
• 5987-73-5 2',3',5'-O-triacetyl-6-chloroinosine 

Downstream Products

• 661471-87-0 5'-O-(4,4'-dimethoxytrityl)-N⁶-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]adenosine 
• 588698-75-3 5’-O-(4,4’-dimethoxytrityl)-2’-O-dimethyl(tert-butyl)silyl-N6-methyladenosine 

Relevant articles and documents

The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis

The straightforward synthesis of eight methylated ribonucleoside phosphoramidites is described. These building blocks allow for incorporation of the naturally occuring nucleosides 1-methylguanosine (m1G), N 2-methylguanosine (m2G), N2N 2-dimethylguanosine (m22G), 1-methylinosine (m1I), 3-methyluridine (m3U), N4- methylcytidine (m4C), N6-methyladenosine (m6A), and N6,N6-dimethyladenosine (m62A) into oligoribonucleotides by automated RNA solid-phase synthesis. In all cases, the ribose 2′-hydroxyl group of the building blocks is masked by the recently introduced [(triisopropylsilyl)oxy]methyl (TOM) group.

Substrate analogues for an RNA-editing adenosine deaminase: Mechanistic investigation and inhibitor design

ADARs are adenosine deaminases that act on RNA and are responsible for RNA-editing reactions that occur in eukaryotic mRNAs, including the mRNAs of glutamate and serotonin receptors. ADARs capable of editing biologically relevant RNA substrates have been