588720-42-7

Basic information

• Product Name: indolizine-6-carboxylic acid
• Synonyms: indolizine-6-carboxylic acid;6-Indolizinecarboxylicacid(9CI);methyl indolizine-6-carboxylate
• CAS NO: 588720-42-7
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.15738
• Product Categories: AMINETERTIARY
• Mol File: 588720-42-7.mol

Chemical Properties

• Appearance: /
• Density: 1.282 g/cm³
• Refractive Index: 1.628
• CAS DataBase Reference: indolizine-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: indolizine-6-carboxylic acid(588720-42-7)
• EPA Substance Registry System: indolizine-6-carboxylic acid(588720-42-7)

Safety Data

• Hazardous Substances Data: 588720-42-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Indolizine-6-carboxylic acid serves as a key building block in organic synthesis, utilized for its ability to be easily modified to incorporate different functional groups. This adaptability makes it a valuable component in the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, indolizine-6-carboxylic acid is applied as a starting material for the development of pharmaceutical compounds. Its structural properties allow for the design of molecules with specific therapeutic targets.
Used in Pharmaceutical Drug Development:
Indolizine-6-carboxylic acid is being investigated for its potential use in the development of new pharmaceutical drugs due to its demonstrated biological activities. Its anti-inflammatory and antioxidant properties are of particular interest, as they may contribute to the treatment of various diseases and conditions.
Used in Research for Biological Activities:
indolizine-6-carboxylic acid is also utilized in research settings to explore its full spectrum of biological activities. Understanding these activities can lead to the discovery of new therapeutic applications and help in designing more effective drugs.

InChI:InChI=1/C9H7NO2/c11-9(12)7-3-4-8-2-1-5-10(8)6-7/h1-6H,(H,11,12)

Upstream product

• 66182-01-2 ethyl indolizine-6-carboxylate 
• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 
• 588720-40-5 ethyl 6-prop-1-ynylnicotinate 

Relevant articles and documents

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemperal dementia (FTD).

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed α7 nAChR agonist, PNU-282,987, while maintaining the compound's other desirable pharmacological properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series (1h, 1o, 2a, 9a, and 18a) shows an improved hERG safety profile over PNU-282,987.

Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease

The invention provides compounds of Formula I: 1These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat conditions or diseases in which α7 is known to be involved.