- METHOD OF PRODUCING UNSYMMETRICAL DISUBSTITUTED PYRIDINE COMPOUNDS
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The present invention relates to a method for producing an asymmetric disubstituted pyridine compound using a position selective Suzuki-Miyaura coupling reaction.
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Paragraph 0232-0235
(2021/01/12)
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- N, C-Disubstituted Biarylpalladacycles as Precatalysts for ppm Pd-Catalyzed Cross Couplings in Water under Mild Conditions
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Various monosubstitution and disubstitution patterns on the parent biarylamine skeleton characteristic of palladacycles, as well as the counterion effect, have been studied while looking for ways to increase the effectiveness of the catalyst formed under micellar catalysis conditions in water, with the goal of reducing the amount of Pd needed for coupling reactions. Several substituted palladacycles containing readily accessible ligands were chosen for evaluation. The results indicate that (1) preactivation of Pd(II) salts as precursors for Suzuki-Miyaura (SM) couplings via treatment with a reducing agent is not required; (2) reactions could be performed with approximately half the loading of Pd, relative to that previously required based on a combination of a Pd(II) salt and ligand; and (3) the most effective palladacycle precatalyst has been identified as that containing an isopropyl group on both an aryl ring and on nitrogen, together with the ligand EvanPhos and triflate as the counterion (P13). This precatalyst is also effective in other C-C bond-forming reactions, such as Heck and Sonogashira couplings. No organic solvents were needed for these processes, while the aqueous reaction medium could be recycled several times. A one-pot, four-step sequence involving Suzuki-Miyaura, reduction, alkylation, and acylation reactions highlights the potential for this precatalyst to maximize synthetic gain while minimizing costs and waste generation.
- Thakore, Ruchita R.,Takale, Balaram S.,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.
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p. 11647 - 11657
(2019/11/29)
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- Bioimaging, antibacterial and antifungal properties of imidazole-pyridine fluorophores: Synthesis, characterization and solvatochromism
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A series of imidazole derivatives connected with pyridine moiety through phenyl groups were synthesized by using Suzuki coupling followed by multicomponent cyclization reaction. Results obtained from spectroscopic ( 1H NMR, 13C NMR,
- Nagarajan,Vanitha,Ananth, D. Arul,Rameshkumar,Sivasudha,Renganathan
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p. 212 - 222
(2013/10/08)
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- PESTICIDAL COMPOSITIONS
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The present invention concerns novel heteroaryl-N-aryl thiosemicarbazones and their use in pest control, as insecticides and acaπcides This invention also includes preparation of the pesticide compositions containing the compounds, and methods of controlling insects using the compounds
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Page/Page column 35
(2011/02/24)
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- PESTICIDAL COMPOSITIONS
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The present invention concerns novel heteroaryl-N-aryl carbamates and their use in pest control, as insecticides and acaricides This invention also includes preparation of the pesticide compositions containing the compounds, and methods of controlling insects using the compounds.
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Page/Page column 35
(2011/02/24)
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- Palladium-catalyzed synthesis of nonsymmetrically functionalized bipyridines, poly(bipyridines) and terpyridines
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Palladium-catalyzed coupling reactions were employed to prepare nonsymmetric, densely functionalized bipyridines and oligo(bipyridines), featuring sensitive functionalities like alcohol, ester and aldehyde groups. Stille coupling between halo (poly)pyridine and the proper (poly)pyridyltin derivative afforded in good yields nonsymmetric, derivatized oligo(bipyridines), amenable to further synthetic modifications. The methodology was used also to synthesize highly functionalized terpyridines. A series of Suzuki and Stille palladium-promoted coupling reactions allowed us to obtain in good yields terpyridines bearing two different and differently functionalizable groups, valuable building blocks for the construction of complex supramolecular frameworks. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
- Puglisi, Alessandra,Benaglia, Maurizio,Roncan, Giulia
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p. 1552 - 1558
(2007/10/03)
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