cas 58962-34-8, 6-KETO-PROSTAGLANDIN F1ALPHA | Articles data ｜lookchem

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58962-34-8

Articles about 58962-34-8Total 7 be found

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Nitro-Olefin Trapping Reactions of Enolates In Situ Generated by Conjugate Addition Reaction: Short Syntheses of PGE1, 6-Oxo-PGE1, 6-Oxo-PGF1α, and PGI2
The nitro-olefin trapping of the enolates in situ generated by conjugate addition of organocopper reagents to the chiral oxygenated cyclopentenone synthon, R-4, gives the three-component coupling products in a regiospecific manner.The intermediary nitronate anion 17 is further transformed into the nitro compound or 6-oxo-PGE1 (19) in a single pot.This coupling reaction is applicable to syntheses of naturally occurring prostaglandins such as PGE1, 6-oxo-PGF1α, and PGI2.
Tanaka, Toshio,Hazato, Atsuo,Bannai, Kiyoshi,Okamura, Noriaki,Sugiura, Satoshi,et al.
p. 813 - 824
(2007/10/02)

Prostacyclin: Evidence that intramolecular general-acid catalysis by its carboxylic acid group is responsible for the extra hydrolytic lability
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Chiang,Cho,Euser,Kresge
p. 4192 - 4196
(2007/10/02)

Short synthesis of 6-oxoprostaglandin E1 and 6-oxoprostaglandin F(1α)
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Tanaka,Hazato,Bannai,et al.
p. 4947 - 4950
(2007/10/02)

Effects of cyclodextrins on the hydrolysis of prostacyclin and its methyl ester in aqueous solution
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Uekama,Hirayama,Wakuda,Otagiri
p. 213 - 219
(2007/10/02)

The synthesis of 2,3-dinorprostacyclin metabolites - A new approach to spirolactone hemiacetals
The major human urinary metabolites of prostacyclin and 6-keto-PGF1α have been synthesized by a direct route, involving three-carbon homologation of bicyclic lactone intermediates and spontaneous spirolactonization of the products. The fact that these 2,3-dinor-6-oxo metabolites exist almost exclusively as spirolactone hemiacetals under acidic conditions (pH 5 and below) may explain the reported difficulties in derivatizing samples of biological origin. Several 19,19.20,20-d4 metabolites have also been synthesized.
Bundy,Lin,Sih
p. 4419 - 4429
(2014/12/11)

Synthesis and stereochemistry of prostacyclin and synthesis of 6 ketoprostaglandin F1α
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Johnson,Lincoln,Thompson,et al.
p. 4182 - 4184
(2007/10/05)

Letter: Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1 alpha in the rat stomach.
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Pace-Asciak
p. 2348 - 2349
(2007/10/16)

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63557-55-1
6-keto-PGF_1α methyl ester

Chemical Properties

Boiling Point: 575.3 °C at 760 mmHg
Flash Point:315.8 °C
Density: 1.191 g/cm³
Solubility:ethanol: 10 mg/mL, clear, faintly yellow
Storage Temp.:−20°C
Vapor Pressure: 1.25E-15mmHg at 25°C
Refractive Index: 1.561
PKA: 4.69±0.10(Predicted)
BRN: 2821925
PSA: 115.06000
LogP: 2.44590

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