The invention relates to novel tenofovir mixed ester-amide prodrugs or pharmaceutically acceptable salts thereof, a preparation method thereof, pharmaceutical compositions containing the prodrug compounds, and application of the prodrugs in preparation of drugs for treating virus infection such as hepatitis B virus (HBV) or human immunodeficiency virus (HIV) infection.
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Paragraph 0090; 0093
(2020/04/17)
ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST - II. ESTERS OF N-ACETYL AMINO ACIDS
D-N-Acetyl amino acid esters were obtained via enantioselective hydrolysis of their racemates by use of fermenting yeast.Evidence is given that proteinases are the enzymes involved.
Glaenzer, B. I.,Faber, K.,Griengl, H.
p. 771 - 778
(2007/10/02)
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