Synthesis of 2-Arylindoles by Rhodium-Catalyzed/Copper-Mediated Annulative Coupling of N-Aryl-2-aminopyridines and Propargyl Alcohols via Selective C-H/C-C Activation
A versatile rhodium-catalyzed/copper-mediated C-H/C-C activation and cascade annulation reaction was described to form 2-arylindole derivatives. Highly selective C-C bond cleavage of ?-substituted tert-propargyl alcohols occurred, together with pyridine-directed ortho C(sp2)-H bond activation, affording a series of 2-arylindoles with yields up to 90%. Subsequent derivations were smoothly conducted to access polyfunctionalized 2-arylindoles, illustrating the potential applications of this method.
Facile assembly of 11 H -indolo[3,2-c]quinoline by a two-step protocol involving a regioselective 6- endo -cyclization promoted by the hendrickson reagent
An expedient approach was developed to construct the 11H-indolo[3,2-c] quinoline scaffold starting from acyclic alkyne substrates. The five- and six-membered nitrogen-containing rings in the tetracyclic skeleton were elaborated efficiently by gold(III)-ca
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an intramolecular coupling reaction of the diazonium group with the indole nitrogen. To obtain the
Cirrincione, Girolamo,Almerico, Anna Maria,Barraja, Paola,Diana, Patrizia,Lauria, Antonino,Passannanti, Alessandra,Musiu, Chiara,Pani, Alessandra,Murtas, Paola,Minnei, Carla,Marongiu, M. Elena,La Colla, Paolo
p. 2561 - 2568
(2007/10/03)
2-Phenyl-indole derivatives and process for preparing the same
New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: STR1 wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl
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(2008/06/13)
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