cas 59-51-8, DL-Methionine | Articles data

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STORAGE-STABLE FORM OF 3-METHYLTHIOPROPIONALDEHYDE
A chemical compound of formula (I), and specific compositions including 3-methylthiopropionaldehyde, 3-methylthiopropane-1,1-diol, a compound of formula I and water, and processes for producing same and also the use of same may be used for the production of 2-hydroxy-4-(methylthio)butyronitrile, methionine hydantoin, methionine. Protected forms may be used for the storage and/or transport of 3-methylthiopropionaldehyde.
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Paragraph 0058-0059

(2021/11/13)

METHOD FOR PRODUCING METHIONINE
An object of the present invention to provide a method for producing methionine with consideration given to the environment. The production method of the present invention comprises a removal step of blowing an inert gas into a liquid containing 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia, and a recovery step of bringing the emission gas into contact with a washing liquid to recover ammonia contained in the emission gas.
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(2021/03/13)

METHOD FOR MANUFACTURING METHIONINE
An object of the present invention is to provide a method for manufacturing methionine capable of achieving an improvement in ammonia removal efficiency. The manufacturing method of the present invention comprises a removal step of supplying a liquid containing a methionine salt, which is obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin and then hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin, to a diffusion tower from an upper portion thereof while supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, and the stripping gas contains a process gas generated in a process of manufacturing methionine.
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Paragraph 0080

(2021/04/02)

SALT-FREE PRODUCTION OF METHIONINE FROM METHIONINE NITRILE
The invention refers to the use of a particulate catalyst containing 60.0 to 99.5 wt.% ZrO2 stabilised with an oxide of the element Hf and at least one oxide of the element M, wherein M = Ce, Si, Ti, or Y, for the hydrolysis reaction of methionine amide to methionine, wherein the median particle size x50 of the particulate catalyst is in the range of from 0.8 to 9.0 mm, preferably of from 1.0 to 7.0 mm. The invention also refers to a process for preparing methionine comprising a step of contacting a solution or suspension comprising methionine amide and water with said particulate catalyst to provide a reaction mixture comprising methionine and/or its ammonium salt from which methionine can be isolated.
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Page/Page column 15-23

(2020/08/22)

PROCESS FOR THE PREPARATION OF METHIONINE
The present invention relates to a process for the preparation of methionine comprising the step of contacting a solution or suspension comprising 2-amino-4-(methylthio)butanenitrile and/or 2-amino- 4-(methylthio)butaneamide with water in the presence of a catalyst to give a methionine comprising mixture, wherein the catalyst comprises CeO2 comprising particles, wherein the CeO2 comprising particles have a BET surface area of from 175 to 300 +/- 10% m2/g measured according to DIN ISO 9277-5 (2003), a mean maximum Feret diameter xFmax, mean of from 3 +/- 10% to 40 +/- 10% nm and a mean minimum Feret diameter xFmin, mean of from 2 +/- 10% to 30 +/- 10% nm, both measured according to DIN ISO 9276-6 (2012).
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Page/Page column 19-21

(2020/12/30)

METHOD FOR PRODUCING METHIONINE
The present invention pertains to a method for producing methionine or salts or derivatives thereof from hydrogen cyanide (HCN), the method comprising a step of producing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN), or a crude product mixture comprising MMP-CN, by contacting a hydrogen cyanide (HCN) process gas mixture prepared according to the Andrussow process from methane, ammonia and oxygen, with 3-methylmercaptopropionaldehyde (MMP), wherein the HCN process gas mixture is obtained from the crude HCN process gas mixture by adjusting the amount of ammonia to between 20 % (v/v) and 60% (v/v) of the amount of the ammonia in the crude HCN process gas mixture.
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Page/Page column 18-19

(2020/07/07)

PROCESS FOR THE PREPARATION OF D,L-METHIONINE
The invention relates to a single cycle process for preparing D,L-methionine from an alkali methioninate solution obtained by alkaline hydrolysis of 5-(2-methylmercaptoethyl)hydantoin, in which the D,L-methionine is obtained by neutralizing the alkali methioninate solution with carbon dioxide at elevated temperature and subsequently crystallizing D,L-methionine in the presence of seed crystals.
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Page/Page column 8-16

(2021/01/22)

METHOD FOR PRODUCING alpha-AMINO ACID
The present invention relates to a method for producing a specified α-amino acid, the method including allowing a specified α-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.
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Paragraph 0150-0156

(2019/06/24)

METHOD FOR PRODUCING METHIONINE AND/OR 2-HYDROXY-4-(METHYLTHIO) BUTANOIC ACID
An object of the invention is to provide a simple method for producing methionine and/or 2-hydroxy-4-(methylthio)butanoic acid at a high yield using 3-(methylthio)propionaldehyde as a raw material. An oxide catalyst containing cerium, 3-(methylthio)propionaldehyde, a compound containing cyanide ion, ammonia or a compound containing ammonium ion, and water are contacted with each other to produce methionine and/or 2-hydroxy-4-(methylthio)butanoic acid.
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Paragraph 0051; 0052; 0055

(2019/03/30)

Economic and high-efficiency methionine preparation method
The invention provides an economic and high-efficiency methionine preparation method. The economic and high-efficiency methionine preparation method comprises the process of hydrolyzing of hydantoin intermediate, such as 5-(beta-methylthio-ethyl)hydantoin, and comprises the following specific steps of (1) mixing the hydantoin intermediate and a small amount of alkaline, sending into a reactor in phase I, and performing loop-open hydrolyzing reaction under the conditions of constant-power low-frequency ultrasonic wave and certain temperature; (2) continuously treating the liquid material in step (1) in a reactor in phase II, thoroughly hydrolyzing under the conditions of power same with the power in step (1) and higher-frequency ultrasonic wave and lower-temperature atmosphere, so as to obtain a saponification liquid of methionine; acidifying, so as to obtain the methionine. The economic and high-efficiency methionine preparation method has the advantages that the hydrolysis reaction efficiency of the hydantoin intermediate in the preparation process of the methionine is improved, and the reaction time is shortened by one time; the reaction temperature is greatly reduced, the hydrolysis yield rate is increased while the generation of side effect is reduced, and the requirement on the material of the reactor is lower.
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Paragraph 0026-0039

(2019/02/04)

Preparation and purification method of amino acid compound
The invention relates to the field of industrial organic synthesis, in particular to a preparation and purification method of an amino acid compound. The method comprises the following steps that (1)alpha-amino nitrile compounds or hydantoin compounds or mixtures thereof are heated to react to obtain alpha-amino acid salt under the condition that volatile alkali and a suitable solvent exist; (2)after the alpha-amino acid salt obtained in step (1) is distilled, the alpha-amino acid salt is recrystallized in an organic solvent to obtain the alpha-amino acid compound. According to the method, reaction conditions are mild, materials can be recycled, and introduction of metal ions and use of ammonium carbonate salt are avoided, so that post-treatment is simple and no waste salt is generated.
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Paragraph 0052; 0053; 0054; 0055; 0056; 0057

(2018/06/21)

A α - amino acid compound synthesis and purification method
The invention relates to a synthesis and purification method for an alpha-amino acid compound. The synthesis and purification method is characterized by comprising the following steps: (1) adding substituted alpha-amino nitrile or a substituted hydantoin-based compound into alkali M(OH)x or metal oxide MxO, adding water or an alcohol and water mixed solvent, and heating for reaction to obtain alpha-amino acid salt; (2) adding ammonium carbonate or ammonium bicarbonate or introducing carbon dioxide into the solution in the step (1), separating to obtain filter liquor and precipitates MxHyCO3, performing reduced pressure concentration on the filter liquor, and recrystallizing in an alcohol solvent to obtain the alpha-amino acid compound (I). The synthesis and purification method for the alpha-amino acid compound is simple, the yield and purity of the obtained alpha-amino acid compound are high; furthermore, recycling utilization and cleaning production of materials can be realized; the synthesis and purification method is especially suitable for synthesis of the alpha-amino acid compound with high water solubility.
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Paragraph 0061; 0062; 0080

(2018/05/16)

METHOD FOR PREPARING METHIONINE
The present invention relates to a method for preparing methionine or methionine salts. In particular, the invention describes the step of preparing 2-hydroxy-4-(methylthio)butyronitrile (MMP-CN) from 3-methylthiopropanal (MMP) and hydrogen cyanide (HCN) in the presence of ammonia by bringing a gaseous mixture comprising HCN and ammonia into contact with MMP.
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Page/Page column 17; 18

(2018/07/29)

METHOD FOR MAKING METHIONINE
The invention concerns a continuous process for manufacturing methionine by alkaline hydrolysis of methionine hydantoin in aqueous phase, removing NH3 and CO2 of the hydrolysis medium, and neutralizing the obtained methioninate salt, according to which, after removal of NH3 and CO2, the hydrolysis reaction medium is concentrated to precipitate Na2CO3, said Na2CO3 being separated then recycled for alkaline hydrolysis, the latter being carried out in the presence of NaOH and Na2CO3.
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Paragraph 0023

(2018/05/03)

METHOD FOR PRODUCING METHIONINE
A method for producing methionine involves contacting 2-amino-4-(methylthio)butanenitrile with water in the presence of an oxide catalyst containing cerium. The 2-amino-4-(methylthio)butanenitrile may be 2-amino-4-(methylthio)butanenitrile, produced by contacting 2-hydroxy-4-(methylthio)butanenitrile with ammonia water or 2-amino-4-(methylthio)butanenitrile, produced by contacting 3-(methylthio)propionaldehyde with hydrocyanic acid and ammonia water.
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Paragraph 0038

(2017/10/10)

Clean production method of methionine
The present invention belongs to the technical field of organic compound production, separation and purification, and particularly relates to a clean production method of methionine. According to the method, 2-amino-4-methylthiobutyronitrile is subjected to hydrolysis by using calcium hydroxide and/or barium hydroxide to prepare methionine calcium/barium, the calcium/barium salt of the byproduct 2,2'-bis-(2-methylthioethyl)iminodiacetic acid is insoluble in water so as to easily separate and purify the methionine calcium/barium and the insoluble byproduct, then the methionine calcium/barium aqueous solution is neutralized by using carbon dioxide to produce the insoluble calcium carbonate/barium and other insoluble precipitates at a high temperature so as to achieve the methionine separation purpose, and the calcium carbonate/barium salt is subjected to calcination to decompose into the carbon dioxide and the oxides, wherein the carbon dioxide and the oxides can be recycled. Compared with the method in the prior art, the method of the present invention has characteristics of low methionine loss rate, high product purity, simple operation, low cost, no low-value inorganic salt production, no emission of a lot of acidic and odor wastewater, and green environmental protection.
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(2017/08/25)

UNSATURATED AMINO ACIDS
There is provided a method of producing at least one unsaturated amino acid from at least one amino acid comprising at least two carbonyl groups, the method comprising (a) contacting a recombinant microbial cell with a medium comprising the amino acid comprising the carbonyl groups, wherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E) selected from the CYP152 10 peroxygenase family, and -at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein.
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Page/Page column 19

(2017/12/13)

Method for environment-friendly clean production of D,L-methionine
A method for environment-friendly clean production of D,L-methionine includes: performing alkaline hydrolysis of 5-(2-methylmercaptoethyl)-hydantoin to obtain carbonate-containing methionine alkali metal saponified solution; then feeding carbon dioxide, crystallizing, and separating to respectively obtain methionine and hydrocarbonate water solution of methionine; subjecting the hydrocarbonate water solution of methionine to chromatographic separation. The method has advantages that loss of D,L-methionine due to pyrolysis can be reduced, simplicity in operation, low cost and high utilization rate of raw materials are realized, high efficiency in acquisition of high-purity methionine crystals is achieved, the purity of the obtained methionine is up to 99.4%, the methionine recovery rate reaches 97%, and the desalinization rate reaches 98% or above. In addition, accumulation of a great quantity of impurities of methionine-containing potassium bicarbonate mother liquor and emission of the potassium bicarbonate mother liquor are avoided, discharge of saline wastewater is avoided, and accordingly environment friendliness and clean production are realized. In a whole process, potassium carbonate serving as a hydrolysis agent is recycled without loss, and replenishment of alkaline potassium compounds is avoided.
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Paragraph 0025; 0026; 0027; 0028; 0029; 0030; 0031-0045

(2017/03/28)

Separation and purification method of D,L-methionine
The invention provides a separation and purification method of D,L-methionine. The separation and purification method is realized through the following steps: hydrolyzing 5-(2-methylthio-ethyl)-hydantoin through an alkaline potassium compound to obtain a potassium methionine saponified solution containing potassium carbonate, introducing carbon dioxide into the saponified solution, crystalizing and separating to obtain methionine and a potassium bicarbonate water solution containing less methionine respectively, carrying out homogeneous membrane electroosmosis, heterogeneous membrane electroosmosis and the like on the potassium bicarbonate water solution respectively. By adopting the method provided by the invention, energy consumption needed by subsequent purification and concentration can be reduced and the operation is simple; the purity of the obtained methionine reaches up to 99.4 percent, the retention rate of the methionine reaches 98.8 percent, and the salt removing rate reaches 99.5 percent; the method can avoid a condition that the methionine is decomposed after being heated for a long time to generate malodorous gas; the method is low in cost, a condition that a lot of acidic and odorous wastewater is discharged is avoided, the method is green and environment-friendly, and the separated potassium bicarbonate can be completely circulated to the step of hydrolyzing the 5-(2-methylthioethyl)-hydantoin; fresh potassium carbonate, potassium bicarbonate or potassium hydroxide does not need to be supplemented.
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Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034-0043

(2017/04/03)

Inexpensive high-purity D, method for the preparation of L-methionine
The invention is directed at the field of chemical engineering and provides a cheap preparation method for high purity D,L-methionine. The preparation method comprises the following steps: preparing a hydrocyanic acid gas mixture by using an Andrussow process; fully reacting the hydrocyanic acid gas mixture with methylthiopropionaldehyde under the catalysis of base so as to prepare a 2-hydroxy-4-methylthiobutyronityile system; reacting the 2-hydroxy-4-methylthiobutyronityile system with ammonia under the conditions of heating and pressurization and carrying out pressure reduction and deamination so as to obtain 2-amino-4-methylthiobutyronityile; and subjecting 2-amino-4-methylthiobutyronityile to acidolysis with inorganic acid so as to obtain D,L-methionine. According to the invention, raw materials used in the method are cheap and easily available, the intermediate 2-hydroxy-4-methylthiobutyronityile has stable properties, prepared 2-amino-4-methylthiobutyronityile has high yield and high purity, and D,L-methionine obtained after continued production has the advantages of high yield, high purity, great bulk density and low total production cost.
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Paragraph 0049; 0052

(2017/02/24)

Comparison of the sustainability metrics of the petrochemical and biomass-based routes to methionine
Sustainability metrics, based on material efficiency, energy input, land use and costs, of three processesfor the manufacture of methionine are compared. The petrochemical process affords dl-methionine whilethe two biomass-based routes afford the l-enantiomer. From the point of view of the major application,in animal feed, either can be used. The first bio-based route, developed by CJ Cheil-Jedang, involves theproduction of an l-methionine precursor, O-succinyl homoserine by fermentation followed by enzymaticreaction of the latter with methyl mercaptan.The second bio-based route involves the isolation of l-methionine from grass protein. Based on thisconcise evaluation of the sustainability metrics we conclude that both bio-based processe are potentiallyattractive sustainable routes for the manufacture of methionine.
Sanders, Johan P.M.,Sheldon, Roger A.
p. 44 - 49
(2015/01/16)

METHOD FOR MANUFACTURING REFINED METHIONINE
The object of the present invention is to provide a process for producing refined methionine in which the loss of methionine due to washing is reduced. The present invention relates to a process for producing refined methionine from crude methionine, comprising a step of washing crude methionine with the use of a wash water containing methionine.
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Paragraph 0068

(2015/01/18)

CLEAN METHOD FOR PREPARING D,L-METHIONINE
The present invention discloses a clean method for preparing a D,L-methionine comprising the steps of: preparing a potassium cyanide solution using a crystallized mother solution containing potassium carbonate as an absorbing liquid to absorb hydrocyanic acid, then reacting the potassium cyanide solution with 3-methylthio propionaldehyde and an ammonium bicarbonate solution at 50-150° C. for 3-15 minutes so as to obtain a 5-(β-methylthioethyl)glycolyurea solution, then bring the 5-(β-methylthioethyl)glycolyurea solution to a temperature of 140-220° C. and subjecting to a saponification reaction for 2-5 minutes, after the completion of the saponification, reducing the temperature to 0-40° C., extracting with an organic solvent, neutralising the water phase with CO2 and crystallizing, then filtering, washing, and drying to obtain an acceptable D,L-methionine product; bring the crystallized D,L-methionine mother solution from filtration to a temperature to 110-160° C. to remove CO2, which are all then circulated and used as a hydrocyanic acid-absorbing liquid. The process route of the present invention is a route suitable for a continuous and clean production, substantially without producing waste water and waste gas.
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Paragraph 0058

(2015/10/28)

METHOD OF PRODUCING METHIONINE
The invention provides the following method capable of producing methionine in a shorter time by making rapid progress of the hydrolysis of 5-(2-methylmercaptoethyl)hydantoin from an aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component. A method of producing methionine is the method comprising hydrolyzing 5-(2-methylmercaptoethyl)hydantoin in an aqueous 5-(2-methylmercaptoethyl)hydantoin solution containing ammonia component, wherein the hydrolysis is performed after the ammonia component is removed from the aqueous solution.
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Paragraph 0040

(2014/06/23)

Method for manufacturing methylmercaptopropionaldehyde and methionine using renewable raw materials
The present invention relates to a method for manufacturing methylmercaptopropionaldehyde (MMP) including at least the following steps: (a) dehydrating glycerol to acrolein from an aqueous solution of glycerol in the presence of an acid catalyst; (b) purifying the aqueous flux from step (a) to obtain a flux of acrolein containing at least 15 wt % of water relative to the acrolein; (c) causing a reaction of the acrolein flux obtained in step (b) with methylmercaptan in the presence of a catalyst; (d) optionally purifying the product obtained in step (c). The method of the invention can also include a reaction of the product obtained in step (c) or (d) with hydrocyanic acid, or sodium cyanide during a step (e) followed by a subsequent transformation to produce methionine or methionine hydroxyanalogue, which can then optionally be purified. The additional use of methylmercaptan and/or hydrocyanic acid derived from biomass as raw materials in the method according to the invention makes it possible to obtain MMP, methionine or methionine hydroxyanalogue made up of 100% organic carbon from renewable sources.
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Page/Page column 16-17

(2014/06/10)

METHOD FOR PRODUCING METHIONINE
A novel method capable of producing methionine without using hydrogen cyanide as a raw material has been desired. The present invention relates to a method for producing methionine including Step A of oxidizing 4-methylthio-2-oxo-1-butanal in the presence of an alcohol, and Step B of reductively aminating 4-methylthio-2-oxo-butyrate obtained in Step A. It is preferable that Step A is carried out by reacting 4-methylthio-2-oxo-1-butanal, the alcohol and an oxidizing agent in the presence of a carbene catalyst.
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Paragraph 0278

(2013/06/28)

METHOD FOR PREPARING AN AMINO ACID FROM 2 AMINOBUTYROLACTONE
The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCH2CH2CHNH2COOH, wherein X is such that X? represents a nucleophilic ion, according to which N-carboxylation of 2-aminobutyrolactone (2ABL) is achieved with carbon dioxide, and the thereby obtained 2ABL carbamate is reactive with an XH reagent or its salts.
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Paragraph 0026; 0027; 0028

(2013/07/25)

METHOD FOR PRODUCING METHIONINE
A novel method for producing methionine without using hydrogen cyanide as a raw material has been demanded. A method for producing methionine including a step A of oxidizing 4-methylthio-2-oxo-1-butanal in the presence of an alcohol; a step B of hydrolyzing a 4-methylthio-2-oxo-butanoic acid ester obtained in the step A; and a step C of subjecting 4-methylthio-2-oxo-butanoic acid obtained in the step B to reductive amination.
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(2013/03/28)

Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding
Reduction of methionine sulfoxide (MetO) residues in proteins is catalyzed by methionine sulfoxide reductases A (MSRA) and B (MSRB), which act in a stereospecific manner. Catalytic properties of these enzymes were previously established mostly using low molecular weight MetO-containing compounds, whereas little is known about the catalysis ofMetOreduction in proteins, the physiological substrates ofMSRAand MSRB. In this work we exploited an NADPH-dependent thioredoxin system and determined the kinetic parameters of yeastMSRAandMSRBusing three different MetO-containing proteins. Both enzymes showed Michaelis-Menten kinetics with the Km lower for protein than for small MetO-containing substrates. MSRA reduced both oxidized proteins and low molecular weight MetO-containing compounds with similar catalytic efficiencies, whereasMSRBwas specialized for the reduction of MetO in proteins. Using oxidized glutathione S-transferase as a model substrate, we showed that both MSR types were more efficient in reducing MetO in unfolded than in folded proteins and that their activities increased with the unfolding state. Biochemical quantificationandidentificationofMetOreducedinthesubstrates by mass spectrometry revealed that the increased activity was due to better access to oxidized MetO in unfolded proteins; it also showed that MSRA was intrinsically more active with unfolded proteins regardless of MetO availability. Moreover, MSRs most efficiently protected cells from oxidative stress that was accompanied by protein unfolding. Overall, this study indicates that MSRs serve a critical function in the folding process by repairing oxidatively damaged nascent polypeptides and unfolded proteins.
Tarrago, Lionel,Kaya, Alaattin,Weerapana, Eranthie,Marino, Stefano M.,Gladyshev, Vadim N.
experimental part
p. 24448 - 24459
(2012/09/08)

Analyses of methionine sulfoxide reductase activities towards free and peptidyl methionine sulfoxides
There have been insufficient kinetic data that enable a direct comparison between free and peptide methionine sulfoxide reductase activities of either MsrB or MsrA. In this study, we determined the kinetic parameters of mammalian and yeast MsrBs and MsrAs for the reduction of both free methionine sulfoxide (Met-O) and peptidyl Met-O under the same assay conditions. Catalytic efficiency of mammalian and yeast MsrBs towards free Met-O was >2000-fold lower than that of yeast fRMsr, which is specific for free Met-R-O. The ratio of free to peptide Msr activity in MsrBs was 1:20-40. In contrast, mammalian and yeast MsrAs reduced free Met-O much more efficiently than MsrBs. Their kcat values were 40-500-fold greater than those of the corresponding MsrBs. The ratio of free to peptide Msr activity was 1:0.8 in yeast MsrA, indicating that this enzyme can reduce free Met-O as efficiently as peptidyl Met-O. In addition, we analyzed the in vivo free Msr activities of MsrBs and MsrAs in yeast cells using a growth complementation assay. Mammalian and yeast MsrBs, as well as the corresponding MsrAs, had apparent in vivo free Msr activities. The in vivo free Msr activities of MsrBs and MsrAs agreed with their in vitro activities.
Kwak, Geun-Hee,Kim, Hwa-Young,Hwang, Kwang Yeon
p. 1 - 5,5
(2020/07/31)

Method for Increasing Methionine Productivity Using a Mixture of Methyl Mercaptan and Dimethyl Sulfide
The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.
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(2012/05/21)

PROCESS FOR PRODUCING METHIONINE
Provided is a process for producing methionine, which involves: (1) hydrolyzing 5-[2-(methylthio)ethylimidazolidine-2,4-dione in the presence of a basic potassium compound, (2) introducing carbon dioxide into a reaction liquid obtained in step (1), thereby precipitating methionine, and separating the resulting slurry into a precipitate and a mother liquid, (3) heat-treating the mother liquid obtained in step (2), and (4) introducing carbon dioxide into the mother liquid heat-treated in step (3), thereby precipitating methionine and potassium bicarbonate, and separating the resulting slurry into a precipitate and a mother liquid, wherein the alanine content in the mother liquid to be subjected to step (4) is 0.75 wt % or less.
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Page/Page column 4-5

(2012/10/08)

PROCESS FOR PRODUCING SULFUR-CONTAINING AMINO ACIDS
The present invention relates to a process for producing a sulfur-containing amino acid, comprising a step of oxidizing a 2-aminoethanol compound having, at position 2, a sulfur-containing hydrocarbon group having 1 to 24 carbon atoms in the presence of copper and water.
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Page/Page column 16-17

(2011/10/31)

PROCESS FOR PRODUCING SULFUR-CONTAINING AMINO ACIDS
The present invention relates to a process for producing a sulfur-containing amino acid, comprising a step of oxidizing a 2-aminoethanol compound having, at position 2, a sulfur-containing hydrocarbon group having 1 to 24 carbon atoms in the presence of oxygen and at least one transition metal selected from the group consisting of the elements of Groups 8, 9 and 10 of the periodic table.
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Page/Page column 16

(2011/10/31)

PROCESS FOR PRODUCING METHIONINE
The present invention relates to a process for producing methionine, comprising a first step of reacting 2-amino-3-buten-1-ol with methanethiol, and a second step of oxidizing 2-amino-4-methylthio-1-butanol obtained in the first step. The present invention also relates to a process for producing 2-amino-4-methylthio-1-butanol, comprising a step of reacting 2-amino-3-buten-1-ol with methanethiol.
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Page/Page column 67-69

(2011/12/14)

PROCESS FOR PRODUCING SULFUR-CONTAINING AMINO ACID OR SALT THEREOF
According to the present invention, a new process for producing a sulfur-containing amino acid without using of hydrogen cyanide or sodium azide which requires careful handling as a raw material can be provided. The present invention relates to a process for producing a sulfur-containing amino acid represented by the following formula (1) or a salt thereof: wherein R1 is an alkyl group having 1 to 12 carbon atoms and optionally having substituents or a cycloalkyl group having 3 to 12 carbon atoms and optionally having substituents, and n is an integral number of from 1 to 4, comprising a step of reacting a sulfur-containing 2-ketocarboxylic acid represented by the formula (2) or a salt thereof: wherein R1 and n mean the same as defined above, with ammonia and hydrogen in the presence of a transition metal catalyst.
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Page/Page column 25-26

(2011/10/13)

PREPARATION OF METHIONINE OR SELENOMETHIONINE FROM HOMOSERINE VIA A CARBAMATE INTERMEDIATE
Provided herein are processes for the production of methionine or selenomethionine from homoserine. In particular, the processes proceed via the production of carbamate intermediates.
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Page/Page column 7

(2011/10/04)

Protein thiocarboxylate-dependent methionine biosynthesis in Wolinella succinogenes
Thiocarboxylated proteins are important intermediates in a variety of biochemical sulfide transfer reactions. Here we identify a protein thiocarboxylate-dependent methionine biosynthetic pathway in Wolinella succinogenes. In this pathway, the carboxy terminal alanine of a novel sulfur transfer protein, HcyS-Ala, is removed in a reaction catalyzed by a metalloprotease, HcyD. HcyF, an ATP-utilizing enzyme, catalyzes the adenylation of HcyS. HcyS acyl-adenylate then undergoes nucleophilic substitution by bisulfide produced by Sir to give the HcyS thiocarboxylate. This adds to O-acetylhomoserine to give HcyS-homocysteine in a PLP-dependent reaction catalyzed by MetY. HcyD-mediated hydrolysis liberates homocysteine. A final methylation completes the biosynthesis. The biosynthetic gene cluster also encodes the enzymes involved in the conversion of sulfate to sulfide suggesting that sulfate is the sulfur source for protein thiocarboxylate formation in this system.
Krishnamoorthy, Kalyanaraman,Begley, Tadhg P.
experimental part
p. 379 - 386
(2011/03/16)

Chemical Reporters of Protein Acylation
Methods and kits for detecting acylated proteins produced by cells that have been cultured or by cells within an organism are provided. Also provided are methods and kits for detecting acylated proteins produced by cells where affinity purification tags are that facilitate detection are used. Compounds useful for the detection of acylated proteins are also provided.
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(2010/08/18)

PROCESS FOR PRODUCING METHIONINE
A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided including the following steps: (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in the step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in the step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in the step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (2).
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Page/Page column 4

(2010/06/11)

PROCESS FOR PRODUCING METHIONINE
A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided, including the following steps: (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (3).
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Page/Page column 4

(2010/06/11)

New polypeptides inducing apoptosis and uses thereof
The present invention concerns a polypeptide comprising the sequence X1WX2X3X4RX5X6X7 X8 X9, and derivatives thereof, wherein X1 is an amino acid selected in the group consisting in histidinc (H), tyrosinc (Y), aspartic acid (D), glutamine (Q), and leucine (L), preferably histidine (H) or tyrosine (Y); X2 is a polar amino acid, charged or not, and selected in the group consisting in serine (S) threonine (T), lysine (K), arginine (R), asparagine (N), aspartic acid (D), cysteine (C), glycine (G), glutamine (Q), histidine (H), and glutamic acid (E); X3 is a polar amino acid, charged or not, and selected in the group consisting in serine (S), threonine (T), asparagine (N), cysteine (C), histidine (H), leucine (L), tyrosine (Y), alanine (A), and isoleucine (1); X4 is an amino acid selected in the group consisting in threonine (T), arginine (R), asparagine (N), alanine (A), isoleucine (I), leucine (L), methionine (M), phenylalanine (F), tryptophane (W), valine (V) and tyrosine; X5 is an amino acid selected in the group consisting in leucine (L), methionine (M), isoleucine (I), tryptophane (W), tyrosine (Y), histidine (H), glutamine (Q), lysine (K), and arginine (R); X6 is an amino acid selected in the group consisting in leucine (L), and glutamic acid (E); X7 is an amino acid selected in the group consisting in cysteine (C), asparagine (N), alanine (A), tyrosine (Y), serine (S), glutamine (Q), and proline (P); X8 is a hydrophobic amino acid selected in the group consisting in alanine (A), isoleucine (I), leucine (L), methionine (M), phenylalanine (F), tryptophane (W), valine (V) and tyrosine; and X9 is a threonine or an hydrophobic amino acid selected in the group consisting in alanine (A), isoleucine (I), leucine (L), methionine (M), phenylalanine (F), tryptophane (W), valine (V) and tyrosine.
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(2009/02/10)

Compositions and Methods for Binding Lysophosphatidic Acid
Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
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(2009/06/27)

Process for producing methionine
The present invention provides a process for producing methionine which is advantageous from the viewpoints of cost and wastewater disposal, and which comprises the following steps (1) to (5): (1) a reaction step comprising hydrolysis of 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) a first crystallization step comprising introduction of carbon dioxide into the reaction solution obtained in step (1) to precipitate methionine, and separation of the resultant slurry into a precipitate and a mother liquor; (3) a second crystallization step comprising concentration of the mother liquor obtained in step (2), mixing with a lower alcohol, introduction of carbon dioxide into the mixture to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor; (4) a heating step comprising concentration of the mother liquor obtained in step (3) followed by a heating treatment at 150 to 200°C; and (5) a third crystallization step comprising introduction of carbon dioxide into the heated mother liquor obtained in step (4) to precipitate methionine and potassium hydrogen carbonate, and separation of the resultant slurry into a precipitate and a mother liquor.
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Page/Page column 6-7

(2009/12/27)

PROCESS FOR PRODUCING METHIONINE
The present invention provides a process for producing methionine, which comprises steps of: hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be produced.
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Page/Page column 4

(2009/12/24)

Method for the production of high-level soluble human recombinant interferon alpha in e. coli and vectors useful for such a production
Method for the production of high-level soluble human recombinant interferon alpha protein (rhuIFNα) in E. coli and vectors useful for such a production. Said method comprises the steps of: (1) Transforming an E. coli selected in the group consisting of E. coli protease deficient host strains, and E. coli reductase deficient host strains, with a recombinant expression vector comprising the sequence encoding the glutathione-S-transferase (GST), a junction sequence including a recognition site for a specific protease and a sequence able to encode an interferon alpha (IFN alpha) protein under the control of an inducible promoter, said vector encoding a GST-IFN alpha fusion protein (2) Expressing said interferon alpha protein in conditions comprising the induction of the expression with 0.1 mM-0.5 mM IPTG and a growth temperature of 25° and/or 37°C, depending on said E. coli strain and (3) Isolating the expressed IFN alpha protein.
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(2009/01/20)

Growth Hormone Secretagogue Receptor 1A Ligands
The present invention relates to new growth hormone secretagogue receptor 1A (GHS-R 1A) ligands, and pharmaceutical compositions comprising any of the new GHS-R1 A ligands. The ligands are suitable for a wide range of applications, and thus the present invention also relates to use of the GHS-R1 A ligands according to the present invention in the manufacture of a medicament for the treatment of an individual in need thereof. In another aspect, the present invention relates to a method of treatment of an individual in need thereof, comprising administering to said individual one or more of the GHS-R1A ligands disclosed herein, such as e.g. for treatment of cancer cachexia.
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(2009/01/20)

Method for production of methionine from homoserine
The invention relates to a method for production of D- and/or L-methionine via D- and/or L-homoserine with subsequent chemical transformation to give methionine.
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Page/Page column 17-18

(2008/06/13)

Cell adhesion and extracellular matrix proteins
Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.
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(2008/06/13)

Process for producing methionine
A process for producing methionine by (1) hydrolyzing 5-[2-(methylthio)ethyl]-2,4-imidazolinedione in the presence of a basic potassium compound; (2) precipitating methionine by introducing CO2 into the reaction solution from the step (1) and separating the slurry into the precipitate and a mother liquid; (3) mixing the mother liquid from the step (2) with an alcohol, precipitating methionine and KHCO3 by introducing CO2 into the mixture, and separating the slurry into the precipitate and a mother liquid; and (4) concentrating the mother liquid from the step (3), precipitating methionine and KHCO3 by introducing CO2 into the concentrated solution, and separating the slurry into the precipitate and a mother liquid.
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Page/Page column 3-4

(2008/06/13)

Chemical Properties

Appearance/Colour :white crystalline powder with a faint odor
Melting Point: 284 °C (dec.)(lit.)
Boiling Point: 306.9 °C at 760 mmHg
Flash Point:139.4 °C
Density: 1.206 g/cm³
Solubility:Sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides
PSA: 88.62000
LogP: 0.85170

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59-51-8

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Chemical Properties

Appearance/Colour :white crystalline powder with a faint odor

Melting Point: 284 °C (dec.)(lit.)

Boiling Point: 306.9 °C at 760 mmHg

Flash Point:139.4 °C

Density: 1.206 g/cm³

Solubility:Sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides

PSA: 88.62000

LogP: 0.85170

Global suppliers and manufacturers of 59-51-8total 343 suppliers on LookChem

Article Database

59-51-8

Articles about 59-51-8Total 168 be found

More Articles about upstream products of 59-51-8

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Chemical Properties

Appearance/Colour :white crystalline powder with a faint odor

Melting Point: 284 °C (dec.)(lit.)

Boiling Point: 306.9 °C at 760 mmHg

Flash Point:139.4 °C

Density: 1.206 g/cm3

Solubility:Sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides

PSA: 88.62000

LogP: 0.85170

Global suppliers and manufacturers of 59-51-8total 343 suppliers on LookChem

Density: 1.206 g/cm³