- HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
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The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.
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Paragraph 0193-0194
(2014/04/03)
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- β-AMINO ACID DERIVATIVES
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The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R8 and R9 are as defined herein, as well as to compositions containing such a compound and the uses of such a compound. Compounds of formula (I) are especially useful in the treatment of pain.
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Page/Page column 49
(2010/11/24)
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- Benzoxazines for use in the treatment of parkinson's disease
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Benzoxazines of Formula (I) wherein R1 is C1-C6 alkyl, C2-C6 alkenyl, or (CH2)n phenyl, R2 is C3-C6 alkyl, R3 is hydrogen, halo, hydro
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Page/Page column 3; 5
(2008/06/13)
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- From imidazoles to pyrimidines: New inhibitors of cytokine release
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On the basis of model imidazole inhibitors of cytokine release, a series of novel pyridinyl pyrimidine derivatives was prepared and tested on their ability to inhibit the release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) from periphera
- Laufer, Stefan A.,Wagner, Gerd K.
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p. 2733 - 2740
(2007/10/03)
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- Correlation Analysis of Reactivity in the Oxidation of Substituted Benzyl Alcohols by Pyridinium Hydrobromide Perbromide
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Oxidation of monosubstituted benzyl alcohols by pyridinium hydrobromide perbromide (PHPB) leads to the formation of the corresponding benzaldehydes.The reaction is first order with respect to PHPB.Michaelis-Menten-type kinetics were observed with respect to he alcohol.The oxidation of α,α-dideuteriobenzyl alcohol indicated the presence of a substantial kinetic isotope effect.The rates of oxidation of meta- and para-substituted benzyl alcohols were correlated in terms of Taft's and Swain's dual substituent-parameter equations.The rates of the meta compounds correlated best with Taft's ?1 and ?0R values whereas the para-compounds showed an excellent correlation with Taft's ?1 and ?R + constants.The rates of the otho-substituted alcohols showed very good correlation with Charton's triparametric equation.The rate increased with an increase in the polarity of the solvent.A mechanism involving a rapid reversible formation of an intermediate complex and its subsequent decomposition in the rate-determining step has been proposed.
- Suri, Deepa,Banerji, Kalyan K.,Kothari, Seema
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p. 1734 - 1758
(2007/10/03)
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