59234-93-4Relevant articles and documents
Useful pro-drug forms of theophylline
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, (2008/06/13)
There is provided novel and useful pro-drug forms of theophylline having the formula: SPC1 Wherein R represents a member selected from the group consisting of a straight or branched C4 -C20 alkyl group, a straight or branched C4 -C20 alkenyl group, a substituted phenyl group of a substituted or unsubstituted naphthyl group whose substituents are selected from the group consisting of a hydroxy group, a C1 -C4 alkyl group, a C1 -C4 alkoxy group, a C1 -C4 acyloxy group, and a halogen atom (Cl, Br, I), and a substituted or unsubstituted heteroaromatic group whose substituents are selected from the group consisting of a hydroxy group, a C1 -C4 alkyl group, a C1 -C4 alkoxy group, a C1 -C4 acyloxy group, and a halogen atom (Cl, Br, I), and wherein A represents a member selected from the group consisting of a --CO-- group, a --CO--(CH2)n --CO-- group, wherein n represents an integer of from 1 to 16, a --CO--CH=CH--CO-- group (cis or trans), a SPC2 Group, and a SPC3 Group. The compounds of this invention are useful in the treatment of asthma in warm-blooded animals. Upon administration, the compounds of this invention slowly go into solution and subsequently cleave prior to and/or during the absorption process, releasing theophylline in a sustained manner at a non-toxic, therapeutic level; that is, without the large blood level variations normally observed when theophylline per se is administered.
