Relocation of aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor
Relocation, relocation: Inactivation of the mitotic kinesin MKLP-2 by a specific small-molecule inhibitor (1) leads to failure in the recruitment of the chromosome passenger protein (survivin, red) to the central spindle (microtubules, green) during anaph
Tcherniuk, Sergey,Skoufias, Dimitrios A.,Labriere, Christophe,Rath, Oliver,Gueritte, Franaoise,Guillou, Catherine,Kozielski, Frank
supporting information; experimental part
p. 8228 - 8231
(2011/02/22)
Benzothiophen analogs as antiviral agents
Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) STR1 wherein R and R1 are as defined herein, and may be in free base or acid addition salt form. Pharmaceutical compositions are provided containing the antiviral agents, as are methods of treating herpes-infected individuals.
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(2008/06/13)
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