- DIAMINE COMPOSITION, AND METHOD OF PREPARING DIISOCYANATE COMPOSITION
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The diamine composition according to an embodiment of the present invention comprises a benzylmonoamine having a methyl group in an amount of 10 ppm to 2,000 ppm in the composition. When it is used for the preparation of a diisocyanate composition and an optical material, it is possible to improve the optical characteristics by preventing the occurrence of yellowing, striae, and cloudiness in the optical material and enhancing the mechanical properties such as impact resistance at the same time. In addition, in the process for preparing a diisocyanate composition according to another embodiment, the b* value according to the CIE color coordinate of a diamine composition is adjusted to a specific range, whereby it is possible to enhance not only the yield and purity of the diisocyanate composition but also the optical characteristics of the final optical lens. Thus, the process for preparing a diisocyanate composition can be applied to the preparation of a plastic optical lens of high quality.
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Paragraph 0261-0263
(2021/06/11)
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- Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein–Protein Interactions
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Stapled peptides are chemical entities in-between biologics and small molecules, which have proven to be the solution to high affinity protein–protein interaction antagonism, while keeping control over pharmacological performance such as stability and mem
- Ali, Ameena M.,Atmaj, Jack,D?mling, Alexander,Groves, Matthew,Holak, Tad A.,Labuzek, Beata,Neochoritis, Constantinos G.,Plewka, Jacek,Ricardo, Manuel G.,Rivera, Daniel G.,Skalniak, Lukasz,Surmiak, Ewa,Zhang, Ran
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supporting information
p. 5235 - 5241
(2020/02/15)
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- Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids
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A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid.
- Goldeman, Waldemar,Nasulewicz-Goldeman, Anna
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supporting information
p. 3475 - 3479
(2014/07/22)
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- Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs)
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A small parallel library of peptoid macrocycles with natural-product- derived side chains of biological importance was produced by Ugi-type multiple multicomponent macrocyclizations including bifunctional building blocks (Ugi-MiBs). Diverse exocyclic elements of high relevance in natural recognition processes, i.e., all functional amino acid residues (e.g., Cys, Arg, His, Trp) and even sugar moieties, can be introduced in a one-pot process into different types of peptoid-containing macrocyclic skeletons. This is exemplified by the use of a diamine/diisocyanide combination of Ugi-MiBs and N-protected α-amino acids or carboxy-functionalized carbohydrates as source for the natural-product-like exocyclic elements. Employed as the acid components of the multiple Ugi reactions, they appear as N-amide substituents on the macrocyclic cores. The use of different diamines and diisocyanides allows an easy variation of the N- to C-directionality and therefore of the position of the exocyclic elements. The Royal Society of Chemistry.
- Rivera, Daniel G.,Vercillo, Otilie E.,Wessjohann, Ludger A.
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experimental part
p. 1787 - 1795
(2008/10/09)
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- A thermally curable mixture
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A thermally curable mixture contains 10-70% by weight of reactive compounds, 0.05-2% by weight of at least one basic catalyst, and at least one solvent. The reactive compounds are consisting essentially of a first reactive compound and a second reactive compound at a molar ratio between 1:1 and 1:10. The first reactive compound is at least one compound selected from polyfunctional amides, and the second reactive compound is at least one compound having an epoxy equivalent between 100 and 800 g KOH per mole epoxy group, selected from a group of aromatic diglycidylethers and aromatic poly-glycidylethers. The basic catalyst is at least one chemical agent selected from the group consisting of tertiary ammonium salts, tertiary aromatic amines, and tertiary heterocyclic amines. The solvent is at least one chemical compound selected from the group consisting of aliphatic alcohols, ether alcohols, diether, and tertiary amides.
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