59290-82-3

Basic information

• Product Name: 3-Nitroisonicotinic acid
• Synonyms: 3-NITRO-4-PYRIDINECARBOXYLIC ACID;3-NITROISONICOTINIC ACID;3-NITROPYRIDINE-4-CARBOXYLIC ACID;3-Nitropyridine-4-carboxylicacid98%;3-NITROPYRIDINE-4-CARBOXYLIC ACID 98%;3-Nitro-4-pyridinecarboxylic acid ,97%
• CAS NO: 59290-82-3
• Molecular Formula: C₆H₄N₂O₄
• Molecular Weight: 168.11
• Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids
• Mol File: 59290-82-3.mol

Chemical Properties

• Melting Point: ca 220℃
• Boiling Point: 467.3 °C at 760 mmHg
• Flash Point: 236.4 °C
• Appearance: /
• Density: 1.57 g/cm³
• Vapor Pressure: 1.56E-09mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.38±0.25(Predicted)
• CAS DataBase Reference: 3-Nitroisonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Nitroisonicotinic acid(59290-82-3)
• EPA Substance Registry System: 3-Nitroisonicotinic acid(59290-82-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 59290-82-3(Hazardous Substances Data)

Usage

Chemical Properties

Light green solid

InChI:InChI=1/C6H4N2O4/c9-6(10)4-1-2-7-3-5(4)8(11)12/h1-3H,(H,9,10)

Upstream product

• 5832-44-0 3-nitro-4-methylpyridine 
• 55-22-1 pyridine-4-carboxylic acid 
• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 

Downstream Products

• 1061358-09-5 3-amino-N-methylisonicotinamide 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 

Relevant articles and documents

Method for rapidly and efficiently synthesizing 3-aminoisonicotinic acid methyl ester (by machine translation)

Of the method for rapidly and efficiently synthesizing 3 - aminoisonicotinic acid methyl ester, through nitration, reduction, to obtain the 3 -aminoisonicotinic acid methyl ester, disclosed by the invention can be repeatedly utilized 3 - to improve the utilization rate, of the raw material and reduce the resource waste, to the maximum reduction . of the whole process . The method comprises the following steps: synthesizing,aminoisonicotinic acid methyl ester in a high, total yield; and reducing resource waste. (by machine translation)

The synthesis of β-nitropyridine compounds

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitro-pyridine 36%, 3-methyl-5-nitropyridinc 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, methyl 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%.