- REVERSIBLE PROTONATION OF A VINYL SELENIDE DURING ITS ACID CATALYZED HYDROLYSIS
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Partially reversible protonation is shown to occur in the course of the acid catalyzed hydrolysis of 2-methylseleno-2 tridecene 1 together with a significant lowering of the kinetic solvent isotope effect (kH2O+/kD2O+= 1.4).
- Piquard, J. L.,Hevesi, L.
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- Oxidative Cleavage of Alkenes by O2with a Non-Heme Manganese Catalyst
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The oxidative cleavage of C═C double bonds with molecular oxygen to produce carbonyl compounds is an important transformation in chemical and pharmaceutical synthesis. In nature, enzymes containing the first-row transition metals, particularly heme and non-heme iron-dependent enzymes, readily activate O2 and oxidatively cleave C═C bonds with exquisite precision under ambient conditions. The reaction remains challenging for synthetic chemists, however. There are only a small number of known synthetic metal catalysts that allow for the oxidative cleavage of alkenes at an atmospheric pressure of O2, with very few known to catalyze the cleavage of nonactivated alkenes. In this work, we describe a light-driven, Mn-catalyzed protocol for the selective oxidation of alkenes to carbonyls under 1 atm of O2. For the first time, aromatic as well as various nonactivated aliphatic alkenes could be oxidized to afford ketones and aldehydes under clean, mild conditions with a first row, biorelevant metal catalyst. Moreover, the protocol shows a very good functional group tolerance. Mechanistic investigation suggests that Mn-oxo species, including an asymmetric, mixed-valent bis(μ-oxo)-Mn(III,IV) complex, are involved in the oxidation, and the solvent methanol participates in O2 activation that leads to the formation of the oxo species.
- Bennett, Elliot L.,Brookfield, Adam,Guan, Renpeng,Huang, Zhiliang,Mcinnes, Eric J. L.,Robertson, Craig M.,Shanmugam, Muralidharan,Xiao, Jianliang
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supporting information
p. 10005 - 10013
(2021/07/19)
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- Highly productive α-alkylation of ketones with alcohols mediated by an Ir-oxalamidato/solid base catalyst system
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An Ir-oxalamidato complex in combination with a solid base (e.g., magnesium aluminometasilicate/Ca(OH)2) significantly improved the catalyst productivity in α-alkylation of methyl ketones with primary alcohols. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000.40 000.
- Maeda, Hironori,Nara, Hideki,Shimizu, Hideo
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supporting information
p. 2772 - 2779
(2020/12/29)
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- Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN
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A mild process using a combination of TMSCl and NaI in acetonitrile is used to regenerate carbonyl compounds from a variety of dithiane and dithiolane derivatives. This easy to handle and inexpensive protocol is also efficient to deprotect oxygenated and mixed acetals as 1,3-dioxanes, 1,3-dioxolanes and 1,3-oxathianes quantitatively. As a possible extension of this method, it was also shown that nitrogenated substrates such as hydrazones, N-tosylhydrazones, and ketimines reacted well under these conditions to give the expected ketones in high yields. The methodology proposed herein is a good alternative to the existing methods since it does not use metals, oxidants, reducing agents, acidic or basic media, and keto-products were obtained in high to excellent yields.
- Yao, Yunxin,Zhao, Guangkuan,Hamze, Abdallah,Alami, Mouad,Provot, Olivier
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p. 5775 - 5779
(2020/08/17)
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- Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source
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Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.
- Kariofillis, Stavros K.,Shields, Benjamin J.,Tekle-Smith, Makeda A.,Zacuto, Michael J.,Doyle, Abigail G.
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supporting information
p. 7683 - 7689
(2020/04/22)
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- Hydrofunctionalization of Olefins to Higher Aliphatic Alcohols via Visible-Light Photocatalytic Coupling
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Abstract: An atomically economical green protocol for the hydrofunctionalization of olefins to higher aliphatic alcohols with 100% anti-Markovnikov regioselectivity was developed via visible-light photocatalytic coupling. This method employs cheap, readily available and abundant methanol as both the C1 feedstock and the hydrogen source under visible light irradiation over CdS photocatalyst. A wide scope of olefin substrates could be hydrofunctionalized successfully to the corresponding higher alcohols with high selectivity. Besides alcohol, acetone and acetonitrile can also couple with olefins to generate the corresponding hydrofunctionalization products, suggesting promising potential industrial application. Graphical Abstract: [Figure not available: see fulltext.] Hydrofunctionalization of olefins to value-added chemicals with high selectivity was achieved via visible-light photocatalytic cross-coupling.
- Bao, Jingxian,Fan, Yonghui,Zhang, Shuyi,Zhong, Liangshu,Wu, Minghong,Sun, Yuhan
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- Hydrogen-transfer reduction of α,β-unsaturated carbonyl compounds catalyzed by naphthyridine-functionalized N-heterocyclic carbene complexes
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Substitution of silver complex of 2-chloro-7-(mesitylimidazolylidenylmethyl)naphthyridine (NpNHC) with palladium(II), rhodium(I) and iridium(I) metal precursors provided [Pd(C,N-NpNHC)(η3-allyl)](BF4) (5), RhCl(COD)(C-NpNHC) (6a) and IrCl(COD)(C-NpNHC) (6b), respectively. Abstraction of chloride from 6a and 6b with AgBF4 provided the chelation complexes [Rh(COD)(C,N-NpNHC)](BF4) (7a) and Ir(COD)(C,N-NpNHC)(BF4) (7b), respectively. All complexes were characterized using NMR and elemental analyses and the structural details of 5 and 6a were further confirmed using X-ray crystallography. In catalytic activity studies, complex 5 was found to be an effective catalyst in the hydrogen-transfer reduction of α,β-unsaturated carbonyl compounds into the corresponding saturated carbonyl compounds.
- Huang, Hsiao-Ching,Ramanathan, Mani,Liu, Yi-Hong,Peng, Shie-Ming,Liu, Shiuh-Tzung
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- Iodine monochloride (ICl) as a highly efficient, green oxidant for the oxidation of alcohols to corresponding carbonyl compounds
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Iodine monochloride (ICl) was discovered to be a highly efficient, green oxidant, which can oxidize aldose hemiacetals, diarylmethanols, arylalkylmethanols, anddialkylmethanols to the corresponding aldose lactones, diarylmethanones, arylalkylmethanones, and dialkylmethanones, respectively, in high yields. ICl as a green, metal-free oxidant is characterized by mild reaction condition, short reaction time, good yield, and broad scope.
- Wei, Peng,Zhang, Datong,Gao, Zhigang,Cai, Wenqing,Xu, Weiren,Tang, Lida,Zhao, Guilong
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supporting information
p. 1457 - 1470
(2015/05/20)
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- 1H-pyrrole-2,4-dicarbonyl-derivatives and their use as flavoring agents
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The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl-derivatives of Formula (I) wherein R1, R2, R3, Z. Z' and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.
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- Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents
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The present invention primarily relates to imidazo[1,2-a]pyridine-ylmethyl-derivatives of Formula (I) wherein R1, R2, X, W e J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.
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- Highly chemoselective and versatile method for direct conversion of carboxylic acids to ketones utilizing zinc Ate complexes
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Various carboxylic acids were directly transformed into the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to the undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity. No need to overreact: Various carboxylic acids were directly transformed to the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity.
- Murata, Ryo,Hirano, Keiichi,Uchiyama, Masanobu
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supporting information
p. 1286 - 1290
(2015/06/08)
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- Ultrastable 3V-PPh3 polymers supported single Rh sites for fixed-bed hydroformylation of olefins
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The heterogenization of homogeneous catalysts is of critical importance for both fundamental research and practical applications. The key obstacle to industrial applications of heterogenized homogeneous catalysts is the long-term stability of the immobilized molecular complexes. We unambiguously demonstrate in this report that the vinyl-functionalized PPh3 polymers supported single Rh sites (Rh/POL-PPh3) catalyst provided not only excellent catalytic activity but also ultrahigh stability for fixed-bed olefins hydroformylation, which is one of the most important industrial homogeneous catalytic processes for the synthesis of aldehydes and alcohols. HAADF-STEM and EXAFS results indicated that the Rh atoms were present in single Rh sites which were strongly coordinated with the exposed phosphorous atoms of the POL-PPh3 support. The Rh/POL-PPh3 catalyst provided high activity and selectivity because it maintained the catalytic functionalities similar to the homogeneous HRh(CO)(PPh3)3 complex, as demonstrated both by 31P MAS NMR and in situ FT-IR experiments. Thus a reaction mechanism, similar to that over the homogeneous HRh(CO)(PPh3)3 complex, was proposed for olefin hydroformylation over the novel Rh/POL-PPh3 catalyst.
- Jiang, Miao,Yan, Li,Ding, Yunjie,Sun, Qi,Liu, Jia,Zhu, Hejun,Lin, Ronghe,Xiao, Fengshou,Jiang, Zheng,Liu, Jingyue
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p. 211 - 217
(2015/06/08)
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- Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes
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There is currently great interest in the development of multistep catalytic processes in which one or several catalysts act sequentially to rapidly build complex molecular structures. Many enzymes - often the inspiration for new synthetic transformations - are capable of processing a single substrate through a chain of discrete, mechanistically distinct catalytic steps. Here, we describe an approach to emulate the efficiency of these natural reaction cascades within a synthetic catalyst by the temporal separation of catalytic activities. In this approach, a single catalyst exhibits multiple catalytic activities sequentially, allowing for the efficient processing of a substrate through a cascade pathway. Application of this design strategy has led to the development of a method to effect the anti-Markovnikov (linear-selective) reductive functionalization of terminal alkynes. The strategy of temporal separation may facilitate the development of other efficient synthetic reaction cascades.
- Li, Le,Herzon, Seth B.
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- Synthetic utility of tribenzyltin hydride and its derivatives as easily accessible, removable, and decomposable organotin reagents
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Radical reactions using tribenzyltin hydride (Bn3SnH) easily prepared from tin and benzyl chloride were studied. The Et3B- initiated reduction and cyclization of haloalkanes and haloalkenes with Bn 3SnH proceeded efficiently. Homolytic hydrostannylation of alkynes with Bn3SnH followed by treatment with electrophiles gave functionalized alkenes in good to high yields. The organotin byproducts formed could be easily removable by filtration and silica-gel column chromatography without any pretreatment. It was also found that tribenzyltin chloride (Bn 3SnCl) easily decomposed to benzyl alcohol in a basic solution of H2O2.
- Yamakawa, Takeshi,Kinoshita, Hidenori,Miura, Katsukiyo
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supporting information
p. 129 - 134
(2013/03/13)
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- PROCESS FOR PRODUCING ALDEHYDES OR KETONES BY OXIDIZING ALCOHOLS WITH OXYGEN
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Provided is a process for producing aldehydes or ketones by oxidizing alcohols with oxygen, which comprises oxidizing alcohols to aldehydes or ketones in an organic solvent at room temperature with oxygen or air as an oxidant, wherein ferric nitrate (Fe(NO3)3.9H2O), 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) and an inorganic chloride are used as catalysts, the reaction time is 1-24 hours, and the molar ratio of said alcohols, 2,2,6,6-tetramethylpiperidine N-oxyl and the inorganic chloride is 100:1?10:1?10:1?10. The present process has the advantages of high yield, mild reaction conditions, simple operation, convenient separation and purification, recoverable solvents, substrates used therefor being various and no pollution, and therefore it is adaptable to industrialization.
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Page/Page column 8
(2012/09/10)
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- Development of a general and practical iron nitrate/TEMPO-catalyzed aerobic oxidation of alcohols to aldehydes/ketones: Catalysis with table salt
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Oxidation of alcohols is a fundamental transformation related to our daily life. Traditional approaches with at least one stoichiometric amount of oxidants are expensive and cause serious environmental burdens. There are many reports on the aerobic oxidation of simple alcohols such as alkyl or phenyl carbinols and allylic alcohols, which used oxygen or air as the environmentally benign oxidant forming water as the only by-product. However, no such protocol has been reported for allenols and propargylic alcohols. Thus, it still highly desirable to develop efficient room temperature oxidations of alcohols with a wide scope including allenols and propargylic alcohols. In this paper, an efficient and clean aerobic oxidation of so far the widest spectrum of alcohols using 1 atm of oxygen or air, producing aldehydes/ketones at room temperature in fairly high isolated yields mostly within a couple of hours is described. It is interesting to observe that the reaction has been efficiently expedited by a catalytic amount of sodium chloride in easily recoverable 1,2-dichloroethane. A mechanism involving NO and NO2 has been proposed based on the results of the control experiments and GC-MS studies of the in-situ formed gas phase of the reaction mixture.
- Ma, Shengming,Liu, Jinxian,Li, Suhua,Chen, Bo,Cheng, Jiajia,Kuang, Jinqiang,Liu, Yu,Wan, Baoqiang,Wang, Yuli,Ye, Juntao,Yu, Qiong,Yuan, Weiming,Yu, Shichao
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experimental part
p. 1005 - 1017
(2011/06/17)
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- Hydroformylation of alkenes using heterogeneous catalyst prepared by intercalation of HRh(CO)(TPPTS)3 complex in hydrotalcite
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Intercalation of HRh(CO)(TPPTS)3 complex into the interlayer space of hydrotalcite was carried out to prepare an eco-friendly heterogeneous hydroformylation catalyst. Intercalated catalyst was characterized by 31P NMR, P-XRD, FT-IR, SEM and surface area measurements. Catalytic activity of intercalated catalyst [HT(3.5)-INT] was evaluated for hydroformylation of linear alkenes of varied carbon number from C5 to C13 as well as cyclic alkenes. Selectivity of the aldehydes was observed to decrease with increase in the carbon chain length of linear alkenes. Effect of reaction parameters on catalytic activity of intercalated catalyst was studied by varying the catalyst amount, 1-hexene concentration, reaction temperature, partial pressure of carbon monoxide and hydrogen for hydroformylation of 1-hexene. The catalyst was re-cycled up to five times without significant loss in the alkene conversion and selectivity of aldehydes.
- Sharma, Sumeet K.,Parikh, Parimal A.,Jasra, Raksh V.
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experimental part
p. 153 - 162
(2010/05/01)
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- Indium-catalyzed radical reductions of organic halides with hydrosilanes
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(Equation Presented) The In(OAc)3-catalyzed reaction of bromo- and iodoalkanes with PhSiH3 in THF at 70°C gave dehalogenated alkanes in good to high yields. In the presence of Et3B and air, the reduction proceeded smoothly at 30°C. When 2,6-lutidine and air were used as additives, the In(OAc)3-catalyzed system enabled an efficient reduction of simple and functionalized iodoalkanes in EtOH. Catalytic use of GaCl3 was found to be effective in the reduction of haloalkanes with poly(methylhydrosiloxane) (PMHS). These catalytic reductions probably involve a radical chain mechanism in which indium or gallium hydride species work as the actual reductants.
- Miura, Katsukiyo,Tomita, Mitsuru,Yamada, Yusuke,Hosomi, Akira
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p. 787 - 792
(2007/10/03)
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- Discovery of a practical direct O2-coupled wacker oxidation with Pd[(-)-sparteine]Cl2
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The discovery of a direct O2-coupled Wacker oxidation with use of balloon pressure of O2 and low catalyst loading is described. Use of (-)-sparteine as a ligand on Pd prevents olefin isomerization and leads to selective formation of methyl ketones from terminal olefins in good yields. Oxidation of enantiomerically enriched substrates is reported with no observed racemization.
- Cornell, Candace N.,Sigman, Matthew S.
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p. 4117 - 4120
(2007/10/03)
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- Ruthenium-catalyzed hydrative dimerization of allenes
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Hydrative dimerization and hydration of allenes proceeded in the presence of a ruthenium catalyst and a strong acid such as trifluoroacetic acid. γ,δ-Unsaturated ketones and methyl ketones were isolated in moderate combined yields. No isomeric compound (isomeric enone) was isolated. Copyright
- Saito, Shinichi,Dobashi, Naotomo,Wakatsuki, Yasuo
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p. 504 - 505
(2007/10/03)
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- Ultrasound mediated synthesis of a few naturally occurring compounds
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Synthesis of 2-methylheptadecane 1, 14-methylpentadecan-3-one 2, 6-oxo-1-nonanol 3, 5-(Z)-undecenoic acid 4 and 2-tridecanone 5 have been accomplished utilizing zinc-copper couple catalyzed conjugate addition of α,β-unsaturated carbonyl compounds under aqueous sonochemical conditions as the key step.
- Singh,Kaur,Nayyar,Bhandari,Kad
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p. 386 - 390
(2007/10/03)
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- Pyrylium salts with long alkyl substituents. III: 2,4-diundecyl-4-methylpyrylium perchlorate and derived pyridinium salts
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The crystalline title pyrylium salt was obtained by SnCl4 catalysed acylation of 2-chloro-2-methylpropane with lauroyl chloride. Some intermediates and by products of the acylation reaction are also described. This new pyrylium salt was converted with high yields into the corresponding pyridine and N-substituted pyridinium salts (N-methyl, N-phenyl, N-(4-n-butylphenyl) and N-dodecyl). These derivatives were characterized by 1H-, 13C-NMR and GC-MS spectra.
- Bogǎ?ian, Mariana,Mihai, Gheorghe,Plaveti, Marieta,Chiraleu, Filip,Deleanu, Cǎlin,Bǎdescu, Virgil,Balaban, Teodor Silviu
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p. 979 - 987
(2007/10/03)
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- Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel β-ketoamides as hypocholesterolemic agents
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A study of structure-activity relationships of substituted β-ketoamide ACAT inhibitors I and II was performed. The results of this study suggest that whereas the β-keto group was tolerated with no loss in activity, β- hydroxy and oxime moieties led to significantly reduced activity in vitro and in vivo. The most potent inhibitor from the acyclic series (I) (11, IC50 = 0.006 μM) contained a C-13 alkyl chain. This compound reduced plasma total cholesterol by 38% and 66% at 3 and 30 mg/kg, respectively, in cholesterol- fed rats. Dimethylation α to the anilide core (5) and subsequent N- methylation of the amide NH (6) decreased in vitro potency significantly. It was also found that high potency was retained with inhibitors which incorporated the carbonyl into a lactam ring (II).
- Augelli-Szafran,Blankley,Roth,Trivedi,Bousley,Essenburg,Hamelehle,Krause,Stanfield
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p. 2943 - 2949
(2007/10/02)
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- The Constituents of the Bark of Litsea elliptica (Lauraceae)
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Extraction of the fresh bark of Litsea elliptica Bl., yielded (+)-reticuline (4) and a steam-volatile oil containing undec-10-en-2-one (1) and tridec-12-en-2-one (2).
- Arbain, Dayar,Dasman,,Ibrahim, Satria,Sargent, Melvyn V.
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p. 1949 - 1952
(2007/10/02)
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- Asymmetric Reduction of Aliphatic Short- to Long-Chain β-Keto Acids by Use of Fermenting Bakers' Yeast
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Eleven β-keto acids, ranging from 3-oxobutanoic to 3-oxooctanoic acids, were reduced with fermenting bakers' yeast to the corresponding optically active β-hydroxy acids, which were isolated as the methyl esters.In all cases, the (R)-hydroxy acids were obtained in >/=98percent ee, except for 3-oxobutanoic acid, which afforded the (S)-hydroxy acid in 86percent ee.Inhibition of fermentation was observed for 3-oxoundecanoic to 3-oxotetradecanoic acids, leading to no reduction.Lowering of the substrate concentration was found to be appreciably effective in avoiding inhibition.
- Utaka, Masanori,Watabu, Hisashi,Higashi, Hiroshi,Sakai, Takashi,Tsuboi, Sadao,Torii, Sigeru
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p. 3917 - 3921
(2007/10/02)
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- Composition and process for augmenting, enhancing or imparting a leather aroma to consumable materials
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Described is the process for augmenting, enhancing or imparting leather aromas to consumable materials including perfume compositions, colognes, perfumed polymers and perfumed articles including solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, hair preparations, cosmetic powders and the like, by adding thereto a composition of matter consisting of the following ingredients: "A": At least one substance having the structure: STR1 in an amount of from about 1% up to about 5% wherein R9 represents C9 -C11 straight-chain alkyl and wherein R10 represents methyl and X is a moiety selected from the group consisting of: STR2 "B": At least one compound having the structure: STR3 in an amount of from about 3 up to about 7% wherein each of R12 -R15 represents hydrogen or C1 -C4 alkyl with the proviso that at least two of R12 -R15 represents hydrogen; "C": At least one compound having the structure: STR4 in an amount of from about 2% up to about 6% wherein R1, R2, R3, R4 and R5 each represents hydrogen or C1 -C4 alkyl with the proviso that one, two or three of R1, R2, R3, R4 and R5 represents C1 -C4 alkyl; "D": Optionally, at least one compound having the structure: STR5 in an amount of from 0% up to about 1.2% wherein R6 represents hydrogen or methyl and R11 represents hydrogen or methyl with the proviso that at least one of R6 or R11 is hydrogen; "E": At least one compound defined according to the structure: STR6 in an amount of from about 30% up to about 70% wherein R7 represents C11, C13, or C15 straight-chain alkyl and R8 represents C1 -C3 lower alkyl; "F": At least one compound having the structure: STR7 in an amount of from about 20% up to about 60% wherein n represents an integer of from 8 up to 28; "G": Optionally, the compound having the structure: STR8 in an amount of from 0 up to about 6%; and "H": Optionally, the compound having the structure: STR9 in an amount of from 0 up to about 6% with the requirement that: STR10 equal 100%.
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- Synthesis of 3-Methyl Fatty Acids
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The synthesis of the 3-methylmyristic, 3-methylpalmitic and 3-methylstearic acids is described.For this purpose, the corresponding methyl ketones were prepared from the lithium salts of fatty acids with shorter chains and methyllithium.The methyl ketones were then reacted with lithiated trimethyl silyl ethyl acetate to give 3-methylalk-2-enoic acid esters which yielded, after hydration and saponification, the 3-methyl fatty acids needed for the synthesis of glycerophospholipids.
- Dobner, B.,Nuhn, P.,Buege, A.,Burkhardt, U.
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- Meerwein Saponification of Alkyl 3-Oxoalkanoates in the Gas Chromatograph
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Alkyl 3-oxoalkanoates decompose by unevitable traces of water in the gas chromatograph to yield the corresponding methyl ketones and alcohols (Meerwein saponification).Decomposition occurs in the hot injector (T= 270 deg C) of the gas chromatograph and also on glass capillary columns (T> 160 deg C).Decomposition in routine work can be avoided by preparing the corresponding 3-trimethylsilyl enol ethers.
- Thoma, Heinz,Spiteller, Gerhard
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p. 1237 - 1248
(2007/10/02)
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