- GLUCOSE UPTAKE INHIBITORS
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this invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are useful for treating diseases, including cancer, autoimmune diseases and inflammation, infectious diseases, and metabolic diseases.
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Paragraph 0217; 0220-0222; 01489; 01491-01493
(2020/01/24)
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- Room temperature C(sp2)-H oxidative chlorination: Via photoredox catalysis
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Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)-H bonds over C(sp3)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.
- Zhang, Lei,Hu, Xile
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p. 7009 - 7013
(2017/10/05)
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- Synthesis of a New Allosteric Carrier Containing Three Conformationally Related Subunits
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A new allosteric carrier was prepared.This compound consists of three crown ether subunits in which conformational information is transferred through two biphenyl systems.This system is able to complex nonionic species in both external crown ether subunits.The allosteric cooperativity in this system was established and its ability to transport Hg(CN)2 has been studied.
- Costero, Ana M.,Pitarch, Miguel
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p. 2939 - 2944
(2007/10/02)
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