Antimycotic Imidazoles. 5. Synthesis and Antimycotic Properties of 1-methyl>-1H-imidazoles
The synthesis of 1-methyl>-1H-imidazoles is described starting with phenylacetyl bromides or 1-(phenylacetyl)imidazoles.The compounds were generally obtained as cis/trans mixtures and found to be active in vitro against dermatophytes, yeasts, other fungi, and Gram-positive bacteria.Some also showed good activity against Candida albicans in vivo.
Heeres, J.,Cutsem, J. Van
p. 1360 - 1364
(2007/10/02)
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