Boron-Catalyzed Dehydrative Friedel-Crafts Alkylation of Arenes Using β-Hydroxyl Ketone as MVK Precursor
Boron-catalyzed environmentally benign dehydrative Friedel-Crafts alkylation of indole/pyrrole and aniline derivatives with β-hydroxyl ketones has been developed for the first time. This method provides an efficient and green replacement of toxic and unst
Ruthenium-Catalyzed Selective C?C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst
Versatile reactive activities of allyl alcohols with free indoles in C?H functionalization reactions were investigated. Direct alkylation or cascade cyclization reactions could be selectively controlled based on the catalyst system: Ru(PPh3)3Cl2 provided C3-substituted β-ketone indoles whereas [Ru(p-cymene)Cl2]2 yielded cyclized indoles.
Xia, Ying-Qi,Li, Chao,Liu, Man,Dong, Lin
supporting information
p. 5474 - 5478
(2018/03/29)
Catalytic C-H bond functionalization with palladium(II): Aerobic oxidative annulations of indoles
A palladium-catalyzed aerobic oxidative annulation of indoles is described. We have demonstrated that a variety of factors influence these cyclizations, and in particular the electronic nature of the pyridine ligand is crucial. It is also remarkable that these oxidative cyclizations can proceed in good yield despite background oxidative decomposition pathways, testament to the facile nature with which molecular oxygen can serve as the direct oxidant for Pd(0). We have also shown that the mechanism most likely involves initial indole palladation (formal C-H bond activation) followed by migratory insertion and β-hydrogen elimination. Copyright
Ferreira, Eric M.,Stoltz, Brian M.
p. 9578 - 9579
(2007/10/03)
More Articles about upstream products of 596105-56-5