59702-08-8

Basic information

• Product Name: 1-ETHYLPIPERAZIN-2-ONE
• Synonyms: 1-Ethyl-piperazin-2-one ,98%;1-Ethyl-piperazin-2-one ,95%;1-ethylpiperazin-2-one(SALTDATA: 1.05HCl 0.2H2O);1-ethylpiperazin-2-one 1.05HCl 0.2H2O;1-ethylpiperazin-2-one hydrochloride;4-Ethyl-3-oxopiperazine;1-Ethyl-2-piperazinone
• CAS NO: 59702-08-8
• Molecular Formula: C₆H₁₂N₂O
• Molecular Weight: 128.1723
• Mol File: 59702-08-8.mol

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.004
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.82±0.20(Predicted)
• CAS DataBase Reference: 1-ETHYLPIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYLPIPERAZIN-2-ONE(59702-08-8)
• EPA Substance Registry System: 1-ETHYLPIPERAZIN-2-ONE(59702-08-8)

Safety Data

• Hazardous Substances Data: 59702-08-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethylpiperazin-2-one is used as a synthetic intermediate for the production of piperidine and piperazine derivatives, which are known for their cognitive-enhancing properties. These derivatives have potential applications in the treatment of cognitive disorders and improving cognitive function in various conditions.
In the synthesis of these derivatives, 1-ethylpiperazin-2-one serves as a crucial component, allowing for the development of new drugs with improved efficacy and safety profiles. Its role in the pharmaceutical industry is essential for the advancement of novel therapeutic agents targeting cognitive impairments and related conditions.

InChI:InChI=1/C6H12N2O/c1-2-8-4-3-7-5-6(8)9/h7H,2-5H2,1H3

Upstream product

• 194350-95-3 tert-butyl 4-ethyl-3-oxopiperazine-1-carboxylate 

Downstream Products

• 1255339-65-1 1-ethyl-4-[3-(4-{1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propyl]piperazin-2-one 
• 1255339-74-2 1-ethyl-4-[2-(4-{1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)ethyl]piperazin-2-one 
• 1240299-78-8 1-ethyl-4-[2-(4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)ethyl]piperazin-2-one 

Relevant articles and documents

PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS

The present disclosure provides compounds of Formula (LA) and/ or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BTK, and are potentially useful for the treatment of diseases treatable by inhibition of ty r-osine kinases such as cancer, inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and/or pharmaceutically acceptable salts thereof and processes for preparing such compounds and p h ar-maceutically acceptable salts thereof

Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

A series of 2-oxopiperazine, 4-aminomethyl-, 3-amino- and 3-aminomethylpiperidine analogues of DM235 (sunifiram) and MN19 (sapunifiram), two previously reported potent cognition-enhancers, have been synthesized and tested in the mouse passive-avoidance test. The compounds display minimal effective doses in the range 0.3-10 mg/kg. Although the new substances do not show improved activity when compared to the parent compounds, some useful information has been obtained to understand structure-activity relationships. In addition, the 3-aminopiperidine moiety appears to be a promising scaffold to synthesize new drugs endowed with cognition-enhancing activity.