Facile synthesis of silyl enol ethers by Mg-promoted coupling of aliphatic carbonyl compounds with trimethylsilyl chloride
Treatment of aliphatic carbonyl compounds with trimethylsilyl chloride with Mg turning for Grignard reaction without any pre-treatment in N,N- dimethylformamide at room temperature brought about highly facile, effective and stereoselective coupling to give the corresponding silyl enol ethers in good yields.
PROCESS FOR PREPARING BICYCLO[2.2.2]OCTANE-1,4-DIOL
Provided is a process for preparing bicyclo[2.2.2]octane-1,4-diol starting from cyclohexane-1,4-dione. The diene is reacted with certain trialkylsilyl halides or trimethylsilyl trifluormethanesulfonate in the presence of a non-nucleophilic base to afford a silyl-substituted diene, which is in turn reacted with ethylene and subsequently reduced to provide the title compound.
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Paragraph 00018
(2021/05/15)
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