597561-78-9Relevant articles and documents
Ring size changes in the development of class I HDAC inhibitors
Cho, Er-Chieh,Liu, Chi-Yuan,Tang, Di-Wei,Lee, Hsueh-Yun
, p. 1387 - 1401 (2021/07/06)
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
Synthesis method of 4-(oxazol-2-yl)benzoic acid
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, (2019/11/14)
The invention relates to a synthesis method of 4-(oxazol-2-yl)benzoic acid. Ethanolamine and 4-carboxybenzaldehyde are used as starting materials, firstly 4-(4,5-dihydroxazol-2-yl)benzoic acid is synthesized, then N-bromosuccinimide and azodiisobutyronitr
DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A MORPHOLINE MOIETY
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Paragraph 0229, (2018/11/21)
The disclosure provides compounds of formula (I) or pharmaceutically acceptable salts thereof: The disclosure also provides processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them, and their use
DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS
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Page/Page column 112, (2016/05/19)
The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, including treating drug dependency and psychosis.
HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
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, (2012/11/08)
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.