599150-20-6

Basic information

• Product Name: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin
• Synonyms: HPI 1;2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroqui;Hh Signaling Antagonist XII, HPI-1;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin;2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquino;2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate;Hedgehog Pathway Inhibitor 1
• CAS NO: 599150-20-6
• Molecular Formula: C27H29NO6
• Molecular Weight: 463.52226
• Mol File: 599150-20-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMSO
• CAS DataBase Reference: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin(599150-20-6)
• EPA Substance Registry System: 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphe nyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin(599150-20-6)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 599150-20-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin is used as a downstream Hh pathway blocker for inhibiting Gli-dependent transcription activity in various cell cultures. Its effectiveness in inhibiting the Hh pathway makes it a potential candidate for the development of therapeutic agents targeting the Hh signaling pathway, which is implicated in various diseases, including cancer and developmental disorders.
Used in Cancer Research:
In cancer research, 2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin is used as a tool compound to study the role of the Hh pathway in cancer development and progression. Its ability to inhibit Gli-dependent transcription activity and ligand-independent Hh pathway activation can provide valuable insights into the molecular mechanisms underlying the Hh pathway's contribution to cancer and help identify potential therapeutic targets.
Used in Developmental Biology Research:
2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin is used as a research tool in developmental biology to investigate the role of the Hh pathway in embryonic development and tissue regeneration. By inhibiting the Hh pathway, researchers can gain a better understanding of its regulatory mechanisms and its impact on normal development and disease processes.

Biological Activity

hedgehog (hh) signaling inhibitor. inhibits sonic hedgehog (shh)-, sag- and gli-induced hh pathway activation in shh-light2 cells (ic50 values are 1.5, 1.5, 4 and 6 μm for shh-, sag-, gli2- and gli1-induced activation). also inhibits hh pathway activation