- Pd-Catalyzed decarboxylative alkynylation of alkynyl carboxylic acids with arylsulfonyl hydrazides via a desulfinative process
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In the presence of a Pd(ii)/P-ligand catalytic system, decarboxylative alkynylation of alkynyl carboxylic acids and arylsulfonyl hydrazides by desulfinative coupling could provide aryl alkynes in satisfactory yields by either judiciously selecting palladium catalysts or modulating phosphine ligands under mild conditions. The reported coupling reactions are very practical as they do not require the protection of inert gas or oxygen and are tolerant to many functional groups.
- Chang, Sheng,Liu, Ying,Yin, Shu Zhu,Dong, Lin Lin,Wang, Jian Feng
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supporting information
p. 5357 - 5362
(2019/04/04)
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- Silver-catalyzed Double Decarboxylative Radical Alkynylation/Annulation of Arylpropiolic Acids with α-keto Acids: Access to Ynones and Flavones under Mild Conditions
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Ynones are privileged building blocks in various organic syntheses of heterocyclic derivatives due to their multifunctional nature, and flavones are an important class of natural products with a wide range of biological activities. We describe the catalytic double decarboxylative alkynylation of arylpropiolic acids with α-keto acids. With Ag(I)/persulfate as the catalysis system, the valuable ynones bearing various substituents could be easily obtained. The introduction of hydroxyl substituent on ortho-site of α-keto acids make this strategy further applicable to the construction of flavone derivatives via heteroannulation in moderate to good yields with a similar silver-catalyzed system. The reactions proceed under relatively mild reaction conditions and tolerate a wide variety of functional groups. Control experiments indicated that both the reactions undergo radical processes. (Figure presented.).
- Meng, Mengting,Wang, Guofang,Yang, Liangfeng,Cheng, Kai,Qi, Chenze
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supporting information
p. 1218 - 1231
(2018/02/16)
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- [Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles
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An efficient [Cu]-catalyzed homocoupling of 1,1-dibromoalk-1-enes is described for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.
- Mahendar, Lodi,Ramulu, Bokka Venkat,Satyanarayana, Gedu
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p. 1151 - 1158
(2017/06/13)
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- FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTIVE AGENTS
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Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the Penicillium chrysogenum species.
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Paragraph 0262; 0263; 0272; 0273
(2015/02/18)
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- FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTANTS
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The present invention relates to formylated xanthocillin analogues for use in the treatment of neurodegenerative diseases, to some of said analogues, as well as to methods for obtaining them and pharmaceutical composition comprising them. The invention al
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Paragraph 0150; 0151; 0160; 0161
(2015/01/18)
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- Synthesis and Physical Properties of Asymmetric Diphenyldiacetylenic Liquid Crystals
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Fifty-six asymmetric diphenyl-diacetylene liquid crystal homologs including dialkyl, alkyl-alkoxy, cyano-alkyl, chloro-alkyl, fluoro-alkyl, difluoro-alkyl, lateral chloro-substituted fluoro-alkyl (or alkoxy), lateral fluoro-substituted asymmetric dialkyl, and vinyl-alkyl are synthesized and their physical properties evaluated.Among these asymmetric diphenyl-diacetylene liquid crystals, many dialkyl homologs exhibit low melting point, wide nematic range, and low heat of fusion.They are ideal host candidates for formulating eutectic mixtures.The polar groups make important contributions to the phase transition temperature, dielectric anisotropy, refractive indices and viscosity.Detailed effects depend on the position of the substitution.These new liquid-crystals compounds and mixtures are particularly useful for electro-optic modulation of infrared radiation. - Keywords: Diphenyl-diacetylenes, eutectic mixtures, electro-optic modulation, physical properties
- Meng, H.-H. B.,Dalton, L. R.,Wu, S.-T.
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p. 303 - 314
(2007/10/02)
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- Substituted benzofurans and benzothiophenes
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The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment angina pectoris.
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