Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO
A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Various potassium aryl carboxylates underwent decarboxylative methylthiolation under air to furnish the corresponding aryl methyl thioethers in moderate to excellent yields. The reaction tolerated a wide variety of functional groups. Notably, the synthesis of ethylthioethers was also successfully achieved directly from diethyl sulfoxide under similar reaction conditions.
Development of the large-scale preparation of 2-(Methanesulfonyl) benzenesulfonyl chloride
A practical and scalable process is described for the preparation of 2-(methansulfonyl)benzenesulfonyl chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpe
Meckler, Harold,Herr, R. Jason
p. 550 - 555
(2012/08/07)
Search for intramolecular H-bonding in thiophenols through UV spectra
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Baljiah,Govindarajan,Gnanasekaran
p. 383 - 386
(2007/10/02)
Process for the nucleophilic substitution of unactivated aromatic and heteroaromatic substrates
The nucleophilic substitution upon unactivated monocyclic or polycyclic aromatic or heteroaromatic substrates bearing suitable leaving groups can be achieved by catalyzing the substitution of said leaving groups by an anionic nucleophile with a cyclic or acyclic polydentate chelating ligand. Specific products of this reaction can be used in preparing sulfonylurea herbicides.
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(2008/06/13)
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