- Microwave-assisted reduction of aromatic nitro compounds with novel oxo-rhenium complexes
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The reduction of several aromatic nitro compounds to amines by means of the two novel catalytic systems ([IMes]2ReOBr3)/PhSiH3 and ([Py]3ReNOBr2)/PhSiH3 under microwave irradiation is here reported. These two systems were able to perform the reduction of nitro groups with higher TON and TOF when compared with previously reported systems based on oxo-rhenium core under standard heating, although they showed a lesser broad reaction scope compared with the known systems.
- Blacque, Olivier,Grieco, Gabriele
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- METALLOENZYME INHIBITOR COMPOUNDS
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Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
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Page/Page column 45
(2020/07/25)
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- 3-OXO-1,4-DIAZEPINYLE COMPOUNDS AS NRF2 ACTIVATORS
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The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I):
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- 3-(2,3-DIHYDRO-1H-INDEN-5-YL)PROPANOIC ACID DERIVATIVES AND THEIR USE AS NRF2 REGULATORS
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The present invention relates to compounds of Formula (I), and Formula (II), wherein B is benzotriazolyl, phenyl, triazolopyridinyl, or -(CH2)2-triazolyl each of which may be unsubstituted or substituted by 1, 2, or 3 substituents independently chosen from -C1-3 alkyl, -O-C1-3 alkyl, CN, - (CH2)2-O-(CH2)2-OR4 and halo; and D is -C(O)OH, -C(O)NHSO2CH3, -SO2NHC(O)CH3, 5-(trifluoromethyl)-4H-1,2,4-triazol-2-yl, or tetrazolyl; and their use as NRF2 regulators.
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Page/Page column 60-61
(2018/06/30)
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- NRF2 REGULATORS
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The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
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- NRF2 REGULATORS
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Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.
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- NRF2 REGULATORS
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The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
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Page/Page column 60; 61
(2017/01/02)
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- NRF2 REGULATORS
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The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
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- Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO22+)
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Benzofuroxans are interesting compounds which display several biochemical and pharmacological properties. Recent studies from our laboratory demonstrate that they are reduced by ferrous salts at room temperature and that the principal reaction products are o-nitroanilines. This paper shows that simple benzofuroxan derivatives are also able to oxidise HbO22+ to methemoglobin (MetHb3+) (UV detection) and to form o-nitroanilines (HPLC detection). From a toxicological point of view this reaction is interesting, since it indicates that the blood is a site for metabolism of these compounds with consequent methemoglobinemia and formation of toxic compounds.
- Medana, Claudio,Visentin, Sonja,Grosa, Giorgio,Fruttero, Roberta,Gasco, Alberto
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p. 799 - 802
(2007/10/03)
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- The reduction of benzofuroxans by ferrous salts and by thiophenol
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Treatment of benzofuroxan derivatives with ferrous sulphate in DMSO/water solution affords in high yield o-nitroanilines. o-Nitroaniline was also obtained by reduction of benzofuroxan with thiophenol in presence of catalytic amount of Fe2+ or Fe3+ salts.
- Gasco,Medana,Gasco
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p. 2707 - 2712
(2007/10/02)
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- o-Nitroaniline Derivatives. Part 8. Synthesis of Some Unsymmetrical Dimethylquinoxalines: A Long-Standing Problem Resolved
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Reduction of N-acetonyl-4-methyl-2-nitro-N-p-tolylsulphonylaniline, using tin(II) chloride in hydrochloric acid, gives 2,7-dimethylquinoxaline (42percent) together with di-p-tolyl disulphide and toluene-p-thiol. 2,6- and 2,5-Dimethylquinoxalines are similarly obtained from the appropriately substituted nitroanilines; the 2,8-dimethyl isomer, however, is obtained impure and in very low yield.
- Blaikley, David C.W.,Currie, David W,Smith, David M.,Watson, Susan A.,McNab, Hamish
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p. 367 - 369
(2007/10/02)
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- Insecticidal (1,1'-biphenyl)-3-ylmethyl esters
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[1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.
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- Insecticidal [1,1'-biphenyl]-3-ylmethyl esters
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[1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.
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